caa a22 4500 475785711 CHVBK 20180406123657.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/PL00014390 doi (NATIONALLICENCE)springer-10.1007/PL00014390 Griffiths Peter Department of Psychology, University of Stirling, Stirling FK9 4LA, Scotland, UK e-mail: pvg1@stir.ac.uk Tel.: +44-1786-467652; Fax: +44-1786-467641, GB aut Neuropsychological approaches to treatment policy issues in phenylketonuria [Elektronische Daten] [Peter Griffiths] Neuropsychological research conducted so far on treatment factors in phenylketonuria suggests that dietary cessation at age 6 is too early. However, continuation of diet until age 10 appears to provide protection against subsequent hyperphenylalaninaemia in the domains of perception, memory and motor skill if concentrations remain at least below 1200 μmol/l thereafter. Levels in the range 360 μmol/l to 600 μmol/l appear to constitute a hazard for executive skill during the pre-school period but in the primary school years the risk diminishes. Levels above 900 μmol/l in early adolescence and adulthood may affect executive abilities adversely and the question remains whether such effects are reversible. Conclusion Though scant, neuropsychological evidence does not seriously contradict current British and German recommendations for dietary control in phenylketonuria. Springer-Verlag Berlin Heidelberg, 2000 Key words Diet therapy nationallicence Neuropsychological assessment nationallicence Phenylketonuria nationallicence Treatment policy nationallicence AbbreviationsHPA hyperphenylalaninaemia nationallicence Phe phenylalanine nationallicence PKU phenylketonuria nationallicence https://doi.org/10.1007/PL00014390 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00014390 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Griffiths Peter Department of Psychology, University of Stirling, Stirling FK9 4LA, Scotland, UK e-mail: pvg1@stir.ac.uk Tel.: +44-1786-467652; Fax: +44-1786-467641, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer