caa a22 4500 475785835 CHVBK 20180406123658.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/PL00014385 doi (NATIONALLICENCE)springer-10.1007/PL00014385 Survey of national guidelines for the treatment of phenylketonuria [Elektronische Daten] [Susanne Schweitzer-Krantz, Peter Burgard] Phenylketonuria treatment policies vary not only between different countries worldwide, but also within one country. Recommendations and guidelines for phenylketonuria should deal with the following subjects: 1. What is the target age to start dietary phenylalanine restriction under newborn-screening conditions? 2. At which plasma phenylalanine concentration should phenylalanine restriction be initiated? 3. Which are the recommended plasma phenylalanine concentrations at different ages? 4. What is the recommended frequency of monitoring phenylalanine in plasma? Statements from the following countries are presented: Czech Republic, Denmark, France, Germany, Great Britain, Hungary, Ireland, Poland, Slovakia and the United States. Conclusion Due to the lack of internationally accepted guidelines, management of phenylketonuria still varies between different countries. Our efforts should focus on the formulation of internationally acceptable and accepted recommendations for the treatment of patients with phenylketonuria at different ages. Springer-Verlag Berlin Heidelberg, 2000 Key words Phenylketonuria nationallicence Dietary treatment nationallicence Guidelines nationallicence Recommendations nationallicence AbbreviationsPhe phenylalanine nationallicence PKU phenylketonuria nationallicence Schweitzer-Krantz Susanne Children's Hospital, Evangelisches Krankenhaus Düsseldorf, Kirchfeldstrasse 40, 40217 Düsseldorf, Germany Tel.: +49-211-9191805; Fax: +49-211-9193980, DE aut Burgard Peter Department of General Paediatrics, University of Heidelberg, Heidelberg, Germany, DE aut https://doi.org/10.1007/PL00014385 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00014385 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schweitzer-Krantz Susanne Children's Hospital, Evangelisches Krankenhaus Düsseldorf, Kirchfeldstrasse 40, 40217 Düsseldorf, Germany Tel.: +49-211-9191805; Fax: +49-211-9193980, DE aut NATIONALLICENCE 700 1- Burgard Peter Department of General Paediatrics, University of Heidelberg, Heidelberg, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer