caa a22 4500 475785894 CHVBK 20180406123658.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004310050060 doi (NATIONALLICENCE)springer-10.1007/s004310050060 Pediatric risk of mortality (PRISM) score in meningococcal disease [Elektronische Daten] [M. J. M. van Brakel, A. J. van Vught, R. J. B. J. Gemke] To assess the pediatric risk of mortality (PRISM) score as a prognostic scoring system in severe meningococcal disease, the files of 53 consecutive patients admitted to a tertiary pediatric intensive care with a clinical diagnosis of meningococcal disease and positive cultures from blood and/or cerebrospinal fluid were analysed. PRISM-score-based expected mortality was compared with observed mortality. Expected mortality in the whole study population was 29% while observed mortality was 19% (P < 0.05). The highest expected and observed mortality was found in septicaemic patients without (documented) meningitis, while meningitis patients without septicaemia had the lowest mortality. All patients with a mortality risk below 18.3% (n = 29) survived whereas all those with a mortality risk of 65% or higher (n = 7) died. Of the 17 patients with a mortality risk between 18.3% and 63.9%, 14 survived and 3 died. The area under the receiver-operating characteristic (ROC) curve was 0.94, which is at least comparable with the best-performing meningococcal-disease-specific scoring systems. Conclusion The PRISM score is a useful generic measure of severity of illness in meningococcal disease and can be used to determine the effectiveness of different treatment strategies. Springer-Verlag Berlin Heidelberg, 2000 Key words Meningococcal infection(s) nationallicence Patient outcome assessment nationallicence PRISM score nationallicence Paediatric intensive care nationallicence van Brakel M. J. M. Paediatric Intensive Care Unit, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85090, 3508 AB Utrecht, The Netherlands Tel.: +31-30-2504000; Fax: +31-30-2505349, NL aut van Vught A. J. Paediatric Intensive Care Unit, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85090, 3508 AB Utrecht, The Netherlands Tel.: +31-30-2504000; Fax: +31-30-2505349, NL aut Gemke R. J. B. J. Paediatric Intensive Care Unit, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85090, 3508 AB Utrecht, The Netherlands Tel.: +31-30-2504000; Fax: +31-30-2505349, NL aut https://doi.org/10.1007/s004310050060 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050060 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Brakel M. J. M. Paediatric Intensive Care Unit, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85090, 3508 AB Utrecht, The Netherlands Tel.: +31-30-2504000; Fax: +31-30-2505349, NL aut NATIONALLICENCE 700 1- van Vught A. J. Paediatric Intensive Care Unit, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85090, 3508 AB Utrecht, The Netherlands Tel.: +31-30-2504000; Fax: +31-30-2505349, NL aut NATIONALLICENCE 700 1- Gemke R. J. B. J. Paediatric Intensive Care Unit, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85090, 3508 AB Utrecht, The Netherlands Tel.: +31-30-2504000; Fax: +31-30-2505349, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer