caa a22 4500 475785940 CHVBK 20180406123658.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004310050069 doi (NATIONALLICENCE)springer-10.1007/s004310050069 Effect of patent ductus arteriosus and indomethacin treatment on serum cardiac troponin T levels in preterm infants with respiratory distress syndrome [Elektronische Daten] [D. Trevisanuto, M. Zaninotto, M. Lachin, S. Altinier, M. Plebani, P. Ferrarese, V. Zanardo] Cardiac troponin T (cTnT) represents a sensitive and specific marker of ischemic myocardial damage in adult and neonatal populations. The aim of this study was to detect the potential ischemic effect of persistent patent ductus arteriosus (PDA) and indomethacin treatment on the coronary vascular bed by measuring cTnT concentrations. cTnT levels were measured in 23 preterm infants (<32 weeks of gestational age) with respiratory distress syndrome (RDS), 11 with PDA and 12 without, at 2, 4, and 7 days after birth. cTnT concentrations (mean ± SEM) significantly decreased (P < 0.05) from the 2nd (0.63 ± 0.09 μg/l) and the 4th (0.77 ± 0.13 μg/l) to the 7th postnatal day (0.28 ± 0.04 μg/l). At day 2 after birth, cTnT levels in preterm infants with RDS were significantly higher (P < 0.05) than our reference values for healthy preterm neonates (0.63 ± 0.09 μg/l vs 0.18 ± 0.04 μg/l). No differences were found between RDS infants with and without PDA at 2 (0.65 ± 0.13 vs 0.61 ± 0.14 μg/l), 4 (0.71 ± 0.21 vs 0.87 ± 0.16 μg/l), and 7 (0.26 ± 0.05 vs 0.29 ± 0.07 μg/l) days of life. In infants with PDA, cTnT levels did not differ before the first dose of indomethacin was given (0.65 ± 0.14 μg/l) or 2 h (0.65 ± 0.15 μg/l) and 48 h (0.71 ± 0.21 μg/l) afterwards. Conclusion In preterm infants with RDS the occurrence of PDA and indomethacin treatment are not associated with ischemic cardiac damage as detected by cTnT measurements. Springer-Verlag Berlin Heidelberg, 2000 Key words Indomethacin nationallicence Patent ductus arteriosus nationallicence Respiratory distress syndrome nationallicence Cardiac troponin T nationallicence Trevisanuto D. Department of Pediatrics, University of Padova, Via Giustiniani 3, 35128 Padova, Italy e-mail: trevo@child.pedi.unipd.it Tel.: +39-049-8213545/46; Fax: +39-049-8213502, IT aut Zaninotto M. Institute of Laboratory Medicine, University of Padova, Italy, IT aut Lachin M. Institute of Laboratory Medicine, University of Padova, Italy, IT aut Altinier S. Institute of Laboratory Medicine, University of Padova, Italy, IT aut Plebani M. Institute of Laboratory Medicine, University of Padova, Italy, IT aut Ferrarese P. Department of Pediatrics, University of Padova, Via Giustiniani 3, 35128 Padova, Italy e-mail: trevo@child.pedi.unipd.it Tel.: +39-049-8213545/46; Fax: +39-049-8213502, IT aut Zanardo V. Department of Pediatrics, University of Padova, Via Giustiniani 3, 35128 Padova, Italy e-mail: trevo@child.pedi.unipd.it Tel.: +39-049-8213545/46; Fax: +39-049-8213502, IT aut https://doi.org/10.1007/s004310050069 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050069 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trevisanuto D. Department of Pediatrics, University of Padova, Via Giustiniani 3, 35128 Padova, Italy e-mail: trevo@child.pedi.unipd.it Tel.: +39-049-8213545/46; Fax: +39-049-8213502, IT aut NATIONALLICENCE 700 1- Zaninotto M. Institute of Laboratory Medicine, University of Padova, Italy, IT aut NATIONALLICENCE 700 1- Lachin M. Institute of Laboratory Medicine, University of Padova, Italy, IT aut NATIONALLICENCE 700 1- Altinier S. Institute of Laboratory Medicine, University of Padova, Italy, IT aut NATIONALLICENCE 700 1- Plebani M. Institute of Laboratory Medicine, University of Padova, Italy, IT aut NATIONALLICENCE 700 1- Ferrarese P. Department of Pediatrics, University of Padova, Via Giustiniani 3, 35128 Padova, Italy e-mail: trevo@child.pedi.unipd.it Tel.: +39-049-8213545/46; Fax: +39-049-8213502, IT aut NATIONALLICENCE 700 1- Zanardo V. Department of Pediatrics, University of Padova, Via Giustiniani 3, 35128 Padova, Italy e-mail: trevo@child.pedi.unipd.it Tel.: +39-049-8213545/46; Fax: +39-049-8213502, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer