caa a22 4500 475785959 CHVBK 20180406123658.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004310050065 doi (NATIONALLICENCE)springer-10.1007/s004310050065 Influence of apolipoprotein E genotypes on serum lipid parameters in a biracial sample of children [Elektronische Daten] [Csaba Szalai, Antal Czinner, Albert Császár]  The goals of this study were to compare the allelic distribution of the apolipoprotein E(apoE) gene in Hungarian and Hungarian Gypsy children and to examine the impact of apoE polymorphism on quantitative levels of lipids in the two racial groups. Our data yielded calculated allele frequencies of 6.4% and 8.9% for apoE2; 83.8% and 73.8% for apoE3; and 9.8% and 17.3% for apoE4 in Hungarian and in Gypsy children, respectively. The frequency of the apoE4 allele was significantly higher (P < 0.05) in Gypsy children than in Hungarians. The effect of apoE genotypes on serum lipid parameters differed considerably in the two racial groups. In the Gypsy group the lowest total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and triglyceride levels were in the E3/E3 group and these values differed significantly (P < 0.0001 for TC and LDL-C and P < 0.01 for triglyceride) from the values in the E2/E3 and E3/E4 groups. There were no significant differences in TC, LDL-C and triglyceride levels between E2/E3 and E3/E4 groups. The high-density lipoprotein-cholesterol (HDL-C) levels did not differ significantly among the genotype groups. In Hungarian children, the apoE2/3 group displayed lower, the E3/4 group higher, values of TC and LDL-C than in the E3/3 group, but the differences were not significant (P > 0.05). HDL-C and triglyceride values did not differ among the genotype groups. Conclusion Our results demonstrate that the apolipoprotein E allele frequencies differ between Hungarian and Gypsy children and suggest that these alleles influence the serum lipid levels, but other genetic and environmental factors can considerably change this effect. Springer-Verlag Berlin Heidelberg, 2000 Key words ApoE alleles nationallicence Serum lipids nationallicence Hungarian and Gypsy children nationallicence Szalai Csaba Heim Pal Paediatric Hospital Central Laboratory Budapest, PO Box 66, H-1958 Hungary e-mail: szalai@heim.sote.hu Tel.: 0036-1-210-0712, Fax: 0036-1-333-0167, HU aut Czinner Antal Heim Pal Paediatric Hospital Central Laboratory Budapest, PO Box 66, H-1958 Hungary e-mail: szalai@heim.sote.hu Tel.: 0036-1-210-0712, Fax: 0036-1-333-0167, HU aut Császár Albert 3rd Department of Internal Medicine, Semmelweis University of Medicine, Budapest, Hungary, HU aut https://doi.org/10.1007/s004310050065 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050065 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Szalai Csaba Heim Pal Paediatric Hospital Central Laboratory Budapest, PO Box 66, H-1958 Hungary e-mail: szalai@heim.sote.hu Tel.: 0036-1-210-0712, Fax: 0036-1-333-0167, HU aut NATIONALLICENCE 700 1- Czinner Antal Heim Pal Paediatric Hospital Central Laboratory Budapest, PO Box 66, H-1958 Hungary e-mail: szalai@heim.sote.hu Tel.: 0036-1-210-0712, Fax: 0036-1-333-0167, HU aut NATIONALLICENCE 700 1- Császár Albert 3rd Department of Internal Medicine, Semmelweis University of Medicine, Budapest, Hungary, HU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer