caa a22 4500 475786009 CHVBK 20180406123658.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004310050062 doi (NATIONALLICENCE)springer-10.1007/s004310050062 Thrombosis of the deep cerebral veins with excessive bilateral infarction in a premature infant with the thrombogenic 4G/4G genotype of the plasminogen activator inhibitor-1 [Elektronische Daten] [Friedrich A. M. Baumeister, Karin Auberger, Karl Schneider] We report on a preterm infant with deep cerebral venous thrombosis, a rare condition in this age group. This premature infant had a gestational age of 33 weeks and normal development until day 18, when he presented with tonic seizures and a tense fontanelle. Ultrasound and computed tomography revealed bilateral haemorrhagic infarction of the whole region drained by the deep cerebral veins, including the periventricular white matter, thalamus and choroid plexus. The child was homozygous for the 4G allele of the plasminogen activator inhibitor-1 (PAI-1) 4G/5G promoter polymorphism. Conclusion In patients with bilateral cerebral infarction, thrombosis of the deep cerebral veins should be considered. In addition the role of prothrombotic risk factors, including PAI-1 4G/5G promoter polymorphism, in cerebral vein thrombosis should be clarified in a multicentre study. Springer-Verlag Berlin Heidelberg, 2000 Key words Thrombosis nationallicence Deep cerebral veins nationallicence Preterm nationallicence Newborn nationallicence Plasminogen activator inhibitor-1 nationallicence Baumeister Friedrich A. M. Kinderklinik und Poliklinik der Technischen Universität München, Kinderklinik Schwabing, Kölner Platz 1, 80804 München, Germany e-mail: u7r11cf@mail.lrz-muenchen.de Tel.: +49-89-30682591, DE aut Auberger Karin Kinderklinik und Kinderpoliklinik im Dr v. Haunerschen Kinderspital der Universität München, Lindwurmstraße 4, 80337 München, Germany, DE aut Schneider Karl Kinderklinik und Kinderpoliklinik im Dr v. Haunerschen Kinderspital der Universität München, Lindwurmstraße 4, 80337 München, Germany, DE aut https://doi.org/10.1007/s004310050062 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050062 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baumeister Friedrich A. M. Kinderklinik und Poliklinik der Technischen Universität München, Kinderklinik Schwabing, Kölner Platz 1, 80804 München, Germany e-mail: u7r11cf@mail.lrz-muenchen.de Tel.: +49-89-30682591, DE aut NATIONALLICENCE 700 1- Auberger Karin Kinderklinik und Kinderpoliklinik im Dr v. Haunerschen Kinderspital der Universität München, Lindwurmstraße 4, 80337 München, Germany, DE aut NATIONALLICENCE 700 1- Schneider Karl Kinderklinik und Kinderpoliklinik im Dr v. Haunerschen Kinderspital der Universität München, Lindwurmstraße 4, 80337 München, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer