caa a22 4500 475786076 CHVBK 20180406123658.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s004310050008 doi (NATIONALLICENCE)springer-10.1007/s004310050008 Neonatal renal venous thrombosis in Germany between 1992 and 1994: epidemiology, treatment and outcome [Elektronische Daten] [A. Bökenkamp, R. von Kries, U. Nowak-Göttl, U. Göbel, P. F. Hoyer] Renal venous thrombosis (RVT) occurs mainly in the neonatal period and bears a dismal prognosis for individual kidney function. There is no generally accepted therapeutic regimen as controlled clinical trials are lacking. Over the last few years, thrombolytic therapy has been successfully employed by single centres. The present study set out to gather up-to-date information on the incidence, therapy and outcome of neonatal RVT as part of a prospective nation wide survey on neonatal thrombosis in Germany to serve as a basis for therapeutic trials in the future. Between 1992 and 1994 the minimum incidence of symptomatic neonatal RVT in Germany was 2.2 per 100,000 live births (95% confidence interval 1.4-3.3). Out of 35 cases, RVT occurred in 15 premature babies (incidence 13 per 100,000 live births (95% confidence interval 5.9-24.8). Ten babies had associated caval occlusion. Therapy was supportive in 8, low dose heparin was used in 14, full heparinization in 9 and thrombolytic therapy in 4 children. On follow-up after a median time of 11.5 months, renal atrophy was present in 26 out of 39 affected kidneys. Conclusion Neonatal renal venous thrombosis still leads to irreversible kidney damage in the majority of cases. Because of the low incidence a multi-national multi-centre therapeutic trial over a long period has to be considered in order to determine the optimal therapeutic approach. Springer-Verlag Berlin Heidelberg, 2000 Key words Renal venous thrombosis nationallicence Neonate nationallicence Incidence nationallicence Therapy nationallicence Outcome nationallicence Bökenkamp A. Children's Hospital, Hannover Medical School, D-30623 Hannover, Germany, DE aut von Kries R. ESPED Registry, University Children's Hospital, D-40225 Düsseldorf, Germany, DE aut Nowak-Göttl U. University Children's Hospital, D-48149 Münster, Germany, DE aut Göbel U. University Children's Hospital, D-40225 Düsseldorf, Germany, DE aut Hoyer P. F. University Children's Hospital, D-45122 Essen, Germany, DE aut https://doi.org/10.1007/s004310050008 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050008 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bökenkamp A. Children's Hospital, Hannover Medical School, D-30623 Hannover, Germany, DE aut NATIONALLICENCE 700 1- von Kries R. ESPED Registry, University Children's Hospital, D-40225 Düsseldorf, Germany, DE aut NATIONALLICENCE 700 1- Nowak-Göttl U. University Children's Hospital, D-48149 Münster, Germany, DE aut NATIONALLICENCE 700 1- Göbel U. University Children's Hospital, D-40225 Düsseldorf, Germany, DE aut NATIONALLICENCE 700 1- Hoyer P. F. University Children's Hospital, D-45122 Essen, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer