caa a22 4500 475786157 CHVBK 20180406123658.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s004310050009 doi (NATIONALLICENCE)springer-10.1007/s004310050009 Erythrocyte fatty acid composition in term infants fed human milk or a formula enriched with a low eicosapentanoic acid fish oil for 4 months [Elektronische Daten] [A. Lapillonne, N. Brossard, O. Claris, B. Reygrobellet, B. L. Salle] When term infants are fed standard formula that does not contain long-chain polyunsaturated fatty acids (LC-PUFA), they still show lower levels of docosahexaenoic acid (DHA) in red blood cell (RBC) phospholipids by several weeks or months postnatally. This study was designed in order to evaluate a potential alternative for supplementing term infant formulas with DHA by adding a high-DHA/low-eicosapentanoic acid fish oil to levels similar to that in human milk (0.3%). A total of 37 term infants were included in the study at 3 days of life. DHA concentrations remained stable between inclusion and 4 months of life at around 8% of the RBC phospholipids in the LC-PUFA enriched formula-fed group whereas it decreased significantly in the standard formula-fed group. In the human milk-fed group, RBC DHA concentrations at 4 months of age were significantly lower than that at birth and were significantly correlated with the duration of breast feeding (r = 0.85; P = 0.0002). A significant decrease of arachidonic acid between inclusion and 4 months of age was observed in the enriched formula-fed group and reached a mean value at 4 months, which was significantly lower than that observed in the human milk or standard formula-fed groups (P < 0.0001). Conclusion Supplementing term formulas with a high-docosahexaenoic acid/low-eicosapentanoic acid fish oil up to 4 months of age is efficient in improving docosahexaenoic acid status, however it increases the risk of impaired n-6 fatty acid status. Springer-Verlag Berlin Heidelberg, 2000 Key words Arachidonic acid nationallicence Docosahexaenoic acid nationallicence Eicosapentaenoic acid nationallicence Fatty acid status nationallicence Term infants nationallicence Lapillonne A. Department of Neonatology, Hopital Edouard Herriot, 69437 Lyon cedex 05, France Tel.: +33-472-11-76-46, Fax: +33-472-11-76-44, FR aut Brossard N. Thallia Pharmaceuticals, Ecully, France, FR aut Claris O. Department of Neonatology, Hopital Edouard Herriot, 69437 Lyon cedex 05, France Tel.: +33-472-11-76-46, Fax: +33-472-11-76-44, FR aut Reygrobellet B. Department of Neonatology, Hopital Edouard Herriot, 69437 Lyon cedex 05, France Tel.: +33-472-11-76-46, Fax: +33-472-11-76-44, FR aut Salle B. L. Department of Neonatology, Hopital Edouard Herriot, 69437 Lyon cedex 05, France Tel.: +33-472-11-76-46, Fax: +33-472-11-76-44, FR aut https://doi.org/10.1007/s004310050009 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050009 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lapillonne A. Department of Neonatology, Hopital Edouard Herriot, 69437 Lyon cedex 05, France Tel.: +33-472-11-76-46, Fax: +33-472-11-76-44, FR aut NATIONALLICENCE 700 1- Brossard N. Thallia Pharmaceuticals, Ecully, France, FR aut NATIONALLICENCE 700 1- Claris O. Department of Neonatology, Hopital Edouard Herriot, 69437 Lyon cedex 05, France Tel.: +33-472-11-76-46, Fax: +33-472-11-76-44, FR aut NATIONALLICENCE 700 1- Reygrobellet B. Department of Neonatology, Hopital Edouard Herriot, 69437 Lyon cedex 05, France Tel.: +33-472-11-76-46, Fax: +33-472-11-76-44, FR aut NATIONALLICENCE 700 1- Salle B. L. Department of Neonatology, Hopital Edouard Herriot, 69437 Lyon cedex 05, France Tel.: +33-472-11-76-46, Fax: +33-472-11-76-44, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer