caa a22 4500 475786270 CHVBK 20180406123659.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s004310050021 doi (NATIONALLICENCE)springer-10.1007/s004310050021 Low serum inhibin B levels as a marker of testicular damage after treatment for a childhood malignancy [Elektronische Daten] [A. Cicognani, E. Cacciari, A. Pasini, R. Burnelli, R. De Iasio, P. Pirazzoli, G. Paolucci] The aim of this study was to evaluate the role of inhibin B and the determination of its concentration to diagnose testicular damage after treatment for a childhood malignancy. Thirty-seven males treated for Hodgkin disease (n=11) or non-Hodgkin lymphoma (n=26) were examined at a mean age of 16.9 ± 2.9 years. Mean age at the stop of therapy was 11.3 ± 3.0 years and in most cases the chemotherapy regimen included gonadal damaging alkylating agents. Thirty-three normal males (mean age 17.9 ± 4.1 years) were examined as controls. Serum samples were collected for determination of inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone. Median inhibin values were significantly lower in patients than in controls (96.0 vs 225.0 pg/ml, P < 0.0001) and a strong negative correlation was found between inhibin B and FSH (r=−0.86, P < 0.0001), a weak correlation with LH (r = −0.32, P < 0.05) and no correlation with testosterone. In post-pubertal patients (i.e., over 16 years) a positive correlation was found between testicular size and inhibin level (r=0.53, P < 0.05), but not between testicular size and testosterone level. Pathological low levels (values that differed by more than 2 SD from the mean value of control subjects) were found in 20 patients for inhibin B and 8 for testosterone (P < 0.01) and pathological high values in 19 patients for FSH and 3 for LH. Conclusion This study confirms the role that inhibin B plays in the regulation of FSH secretion and provides further evidence of the utility of its evaluation as a direct indicator of male gonadal dysfunction. Springer-Verlag Berlin Heidelberg, 2000 Key words Inhibin B nationallicence Follicle-stimulating hormone nationallicence Gonadal damage nationallicence Seminiferous tubule nationallicence Sertoli cell function nationallicence Cicognani A. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut Cacciari E. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut Pasini A. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut Burnelli R. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut De Iasio R. Department of Clinical Pharmacology, University of Bologna, Bologna, Italy, IT aut Pirazzoli P. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut Paolucci G. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut https://doi.org/10.1007/s004310050021 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050021 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cicognani A. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut NATIONALLICENCE 700 1- Cacciari E. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut NATIONALLICENCE 700 1- Pasini A. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut NATIONALLICENCE 700 1- Burnelli R. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut NATIONALLICENCE 700 1- De Iasio R. Department of Clinical Pharmacology, University of Bologna, Bologna, Italy, IT aut NATIONALLICENCE 700 1- Pirazzoli P. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut NATIONALLICENCE 700 1- Paolucci G. Department of Pediatrics, Pediatric Clinic I, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy e-mail: ped1@alma.unibo.it Tel.: +39-051-6363643; Fax: +39-051-51-390070, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer