caa a22 4500 475786335 CHVBK 20180406123659.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s004310050006 doi (NATIONALLICENCE)springer-10.1007/s004310050006 Pubertal development and growth after total-body irradiation and bone marrow transplantation for haematological malignancies [Elektronische Daten] [B. Bakker, G. G. Massa, W. Oostdijk, M. H. Van Weel-Sipman, J. M. Vossen, J. M. Wit] Pubertal development after total-body irradiation (TBI) was investigated in 40 children (21 boys) treated with allogeneic bone marrow transplantation (BMT) for haematological malignancies at a mean age of 11.3 years. The mean age at the last visit was 19.0 years. Twenty-five patients (15 boys) were prepubertal at BMT. Data on secondary sexual characteristics, the pituitary-gonadal axis and longitudinal growth were retrospectively collected from the medical records. In boys not receiving additional testicular irradiation (n = 19), penile growth and pubic hair development was normal and all had serum testosterone levels within the adult range. The majority of them, however, had incidental elevations of LH, suggesting minor Leydig cell damage. Testicular volume at last measurement was small (mean: 10.5 ml) and serum FSH levels were elevated in all boys, with normalisation in only one, suggesting severe impairment of reproductive gonadal function. Of the ten girls who received BMT before puberty, six had a spontaneous onset of puberty and menarche; the four other girls needed hormonal substitution therapy. Recovery of gonadal function after cessation of substitution was seen in one girl, who became pregnant but had a spontaneous abortion. Decrease in height SDS was seen in the majority of patients and was positively correlated with male gender and lower age at the time of BMT. Conclusion Careful monitoring of both gonadal function and growth after bone marrow transplantation and total body irradiation is warranted in order to detect disturbances early and ensure normal pubertal development in children treated for haematological malignancies. Springer-Verlag Berlin Heidelberg, 2000 Key words Bone marrow transplantation nationallicence Whole-body irradiation nationallicence Haematological neoplasms nationallicence Puberty nationallicence Bakker B. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut Massa G. G. Department of Paediatrics, Virga Jesse Hospital, Hasselt, Belgium, BE aut Oostdijk W. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut Van Weel-Sipman M. H. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut Vossen J. M. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut Wit J. M. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut https://doi.org/10.1007/s004310050006 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050006 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bakker B. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut NATIONALLICENCE 700 1- Massa G. G. Department of Paediatrics, Virga Jesse Hospital, Hasselt, Belgium, BE aut NATIONALLICENCE 700 1- Oostdijk W. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut NATIONALLICENCE 700 1- Van Weel-Sipman M. H. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut NATIONALLICENCE 700 1- Vossen J. M. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut NATIONALLICENCE 700 1- Wit J. M. Department of Paediatrics, J6-S, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands e-mail: bbakker@kindjc.azl.nl Tel.: +31-71-526-1663; Fax: +31-71-524-8198, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer