caa a22 4500 475786343 CHVBK 20180406123659.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s004310050007 doi (NATIONALLICENCE)springer-10.1007/s004310050007 Primary infantile hypomagnesaemia: outcome after 21 years and treatment with continuous nocturnal nasogastric magnesium infusion [Elektronische Daten] [D. E. C. Cole, S. W. Kooh, R. Vieth] Primary infantile hypomagnesaemia is an infrequent cause of neonatal hypocalcaemic seizures but one that responds well to magnesium supplementation. We describe a 22-year-old male, first reported at 4 months of age, who is currently free of neurological deficit but has suffered from intermittent hypomagnesaemic tetany and chronic diarrhoea due to large oral magnesium supplements. Hypothesizing that modest hypercalcaemia might prevent the tetany, we conducted a trial of 5 μg/day 1,25(OH)2D3 over 5 days. Despite the resultant increase in calcium, he developed tetany with the reduction of magnesium intake and decline of serum magnesium from 0.63 to 0.39 mmol/l (normal >0.65 mmol/l). After 1,25(OH)2D3 was stopped and the parenteral magnesium injections suspended, 33% of his usual oral supplement was given instead by continuous nasogastric infusion and serum magnesium rose to 0.60 mmol/l. This regimen was better tolerated because of decreased gastrointestinal side-effects and freedom from parenteral injections. We observed that 1,25(OH)2D3 supplements do not promote magnesium retention nor does the resultant hypercalcaemia prevent hypomagnesaemic tetany. Conclusion Continuous nocturnal nasogastric infusion may be considered in lieu of parenteral therapy in primary infantile hypomagnesaemia. Springer-Verlag Berlin Heidelberg, 2000 Key words Hypomagnesaemia nationallicence Tetany nationallicence Calcitriol nationallicence Nasogastric infusion nationallicence Calcium metabolism nationallicence Cole D. E. C. Department of Laboratory Medicine and Pathobiology, Room 402, Banting Institute, 100 College Street, Toronto, Ontario M5G 1L5, Canada e-mail: davidec.cole@utoronto.ca Tel.: +1-416-978-6720, Fax: +1-416-978-5650, CA aut Kooh S. W. Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada, CA aut Vieth R. Department of Laboratory Medicine and Pathobiology, Room 402, Banting Institute, 100 College Street, Toronto, Ontario M5G 1L5, Canada e-mail: davidec.cole@utoronto.ca Tel.: +1-416-978-6720, Fax: +1-416-978-5650, CA aut https://doi.org/10.1007/s004310050007 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050007 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cole D. E. C. Department of Laboratory Medicine and Pathobiology, Room 402, Banting Institute, 100 College Street, Toronto, Ontario M5G 1L5, Canada e-mail: davidec.cole@utoronto.ca Tel.: +1-416-978-6720, Fax: +1-416-978-5650, CA aut NATIONALLICENCE 700 1- Kooh S. W. Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada, CA aut NATIONALLICENCE 700 1- Vieth R. Department of Laboratory Medicine and Pathobiology, Room 402, Banting Institute, 100 College Street, Toronto, Ontario M5G 1L5, Canada e-mail: davidec.cole@utoronto.ca Tel.: +1-416-978-6720, Fax: +1-416-978-5650, CA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer