caa a22 4500 475786416 CHVBK 20180406123659.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00013811 doi (NATIONALLICENCE)springer-10.1007/PL00013811 Carotenoid supply in breast-fed and formula-fed neonates [Elektronische Daten] [Olaf Sommerburg, Kristina Meissner, Mathias Nelle, Henning Lenhartz, Michael Leichsenring] Carotenoids have various biological functions including their role as antioxidants. For humans fruits and vegetables are the only source of carotenoids. In the first months breast milk and/or formula preparations are the only nutrition for infants. To study the influence of nutrition on the plasma carotenoid profile in newborns, breast milk, different formula preparations, and the plasma of breast-fed (BF) and formula-fed (FF) newborns were analyzed by high-performance liquid chromatography. The method used allowed β-carotene, α-carotene, lycopene, and β-cryptoxanthine to be detected and all four were found in breast milk. In colostrum carotenoids were up to five times higher than in mature breast milk (P < 0.05). In contrast, not all carotenoids could be found in formula preparations. β-Carotene was detected in four out of eight, and β-cryptoxanthine in three out of eight formula preparations. Lycopene and α-carotene were not detectable in any of the formula preparations. Four formula preparations did not contain any carotenoids. FF infants had different plasma carotenoid profiles compared to BF infants. β-Carotene was significantly lower in FF infants [14 (0-32) μg/l, median and interquartile ranges] than in infants after birth [24 (19-310) μg/l, P < 0.05], and BF infants [32 (22-63) μg/l, P < 0.05]. While newborns after birth had measurable plasma concentrations of lycopene (16 [14-18] μg/l) and of α-carotene [5 (0-8) μg/l), these carotenoids were no longer detectable in FF infants after day 14. Conclusion FF and BF infants show significant biochemical differences in plasma carotenoid concentrations. Springer-Verlag Berlin Heidelberg, 2000 Key words Carotenoids nationallicence Nutrition nationallicence Breast milk nationallicence Formula preparation nationallicence Newborns nationallicence Sommerburg Olaf University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut Meissner Kristina University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut Nelle Mathias University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut Lenhartz Henning University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut Leichsenring Michael University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut https://doi.org/10.1007/PL00013811 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00013811 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sommerburg Olaf University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut NATIONALLICENCE 700 1- Meissner Kristina University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut NATIONALLICENCE 700 1- Nelle Mathias University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut NATIONALLICENCE 700 1- Lenhartz Henning University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut NATIONALLICENCE 700 1- Leichsenring Michael University Children's Hospital, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany e-mail: olaf_sommerburg@med.uni-heidelberg.de Tel.: +49-6221-562311, Fax: +49-6221-564624, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer