caa a22 4500 475786424 CHVBK 20180406123659.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/PL00013806 doi (NATIONALLICENCE)springer-10.1007/PL00013806 Postoperative Mycobacterium avium osteomyelitis confirmed by polymerase chain reaction [Elektronische Daten] [J. A. I. Weigl, W. H. Haas] An 18-year-old male with Escobar syndrome developed Mycobacterium avium osteomyelitis after corrective osteotomy. After three surgical interventions the infection reappeared a fourth time. Repeated attempts at microbiological diagnosis of the granulomatous lesions by microscopy and culture for conventional bacteria and Mycobacteria did not reveal any organism. The diagnosis of Mycobacterium avium finally was achieved by polymerase chain reaction. Extensive immunological work-up did not reveal signs of immunodeficiency. The patient was treated successfully by a combined surgical and chemotherapeutic approach consisting of clarithromycin, ethambutol and ciprofloxacin. Conclusion Polymerase chain reaction may be especially useful for clinical situations with a low bacterial load, especially for fastidious and slow growing pathogens like Mycobacteria. In our patient a combination of surgical therapy with a triple regimen containing clarithromycin proved successful for treatment of a localised infection with M. avium in a supposedly immunocompetent host. Springer-Verlag Berlin Heidelberg, 2000 Key wordsMycobacterium avium nationallicence Osteomyelitis nationallicence Wound infection nationallicence Polymerase chain reaction nationallicence Weigl J. A. I. Paediatric Infectious Diseases, Children's Hospital Kiel, Schwanenweg 20, 24105 Kiel, Germany Fax: +49-431-597 1680, DE aut Haas W. H. Molecular Biology Laboratory, Department of General Paediatrics, Children's Hospital Heidelberg, Germany, DE aut https://doi.org/10.1007/PL00013806 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00013806 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weigl J. A. I. Paediatric Infectious Diseases, Children's Hospital Kiel, Schwanenweg 20, 24105 Kiel, Germany Fax: +49-431-597 1680, DE aut NATIONALLICENCE 700 1- Haas W. H. Molecular Biology Laboratory, Department of General Paediatrics, Children's Hospital Heidelberg, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer