caa a22 4500 475786483 CHVBK 20180406123659.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s004310000500 doi (NATIONALLICENCE)springer-10.1007/s004310000500 Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome in childhood: a report of ten cases and review of the literature [Elektronische Daten] [Benedetta C. Beretta-Piccoli, Marie J. Sauvain, Imre Gal, Andreas Schibler, Traudel Saurenmann, Helene Kressebuch, Mario G. Bianchetti] Chronic recurrent multifocal osteomyelitis is a rare chronic inflammatory musculoskeletal process observed in children and young adults. Recently, the acronym SAPHO syndrome (for synovitis, acne, pustulosis, hyperostosis, osteitis) was coined to emphasise the association between osteo-articular inflammations and different skin abnormalities which are aseptic and filled with neutrophils. In adults, chronic recurrent multifocal osteomyelitis is now a classical manifestation of SAPHO syndrome. Chronic skin disorders were seen in eight of ten children on follow-up at the University Children's Hospitals in Bern and Zurich and in 61 of 260 paediatric cases reported in the literature. The different skin lesions were palmoplantar pustulosis (n=40), non-palmoplantar pustulosis (n=6), psoriasis vulgaris (n=16) or severe acne (n=4). More rarely Sweet syndrome (n=2) or pyoderma gangrenosum (n=1) were reported. Conclusion The synovitis, acne, pustulosis, hyperostosis, osteitis syndrome is pertinent even in paediatrics since skin involvement is frequent. Springer-Verlag Berlin Heidelberg, 2000 Key words Acne nationallicence Ankylosing spondylitis nationallicence Arthritis nationallicence Chronic recurrent multifocal osteomyelitis nationallicence Osteomyelitis nationallicence SAPHO syndrome nationallicence Skin diseases nationallicence Beretta-Piccoli Benedetta C. Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut Sauvain Marie J. Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut Gal Imre Department of Radiology, University of Bern, Bern, Switzerland, CH aut Schibler Andreas Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut Saurenmann Traudel Department of Paediatrics, University of Zurich, Zurich, Switzerland, CH aut Kressebuch Helene Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut Bianchetti Mario G. Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut https://doi.org/10.1007/s004310000500 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310000500 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beretta-Piccoli Benedetta C. Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut NATIONALLICENCE 700 1- Sauvain Marie J. Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut NATIONALLICENCE 700 1- Gal Imre Department of Radiology, University of Bern, Bern, Switzerland, CH aut NATIONALLICENCE 700 1- Schibler Andreas Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut NATIONALLICENCE 700 1- Saurenmann Traudel Department of Paediatrics, University of Zurich, Zurich, Switzerland, CH aut NATIONALLICENCE 700 1- Kressebuch Helene Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut NATIONALLICENCE 700 1- Bianchetti Mario G. Department of Paediatrics, University of Bern, Inselspital, 3010 Bern, Switzerland e-mail: mario.bianchetti@insel.ch, CH aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer