caa a22 4500 475786505 CHVBK 20180406123659.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s004310000452 doi (NATIONALLICENCE)springer-10.1007/s004310000452 Lagae Lieven Department of Paediatric Neurology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium e-mail: lieven.lagae@uz.kuleuven.ac.be, Tel.: +32-16-343834; Fax: +32-16-343842, BE aut Cortical malformations: a frequent cause of epilepsy in children [Elektronische Daten] [Lieven Lagae] In this review, a simplified scheme for classification of cortical malformations is introduced and illustrated based on the work of Barkovich et al. [8]. Detailed MRI studies identify cortical malformations as a major cause of epilepsy in children. Two aspects that are becoming increasingly important for the paediatrician are emphasised. First, knowledge of the genetic background of cortical malformations is necessary for appropriate genetic counselling. Although the majority of cortical malformations occur sporadically, recent studies have shown a familial pattern in specific epilepsy syndromes associated with cortical malformations. Second, the epilepsy becomes refractory to the common anti-epileptic drugs in many patients with cortical malformations so that epilepsy surgery should be considered. In this respect, the paediatrician can play a pivotal role in referring candidate patients for further specialised assessment. Conclusion The input of the paediatrician will become crucial to link clinical, genetic and neuro-imaging data in children with the great variety of possible cortical malformations. Springer-Verlag Berlin Heidelberg, 2000 Key words Epilepsy nationallicence Cortical malformations nationallicence Migration disorders nationallicence Magnetic resonance imaging nationallicence Brain development nationallicence https://doi.org/10.1007/s004310000452 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310000452 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lagae Lieven Department of Paediatric Neurology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium e-mail: lieven.lagae@uz.kuleuven.ac.be, Tel.: +32-16-343834; Fax: +32-16-343842, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer