caa a22 4500 475786599 CHVBK 20180406123700.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s004310000507 doi (NATIONALLICENCE)springer-10.1007/s004310000507 Detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis: a review [Elektronische Daten] [Jasmine Leus, Stéphanie Van Biervliet, Eddy Robberecht] Pancreatic function testing is particularly difficult when the degree of remaining function has to be quantified. Detection of pancreatic insufficiency can suggest the diagnosis of cystic fibrosis (CF). It is, however; also important to follow the degree of pancreatic insufficiency in CF since its function can decline with age. Adaptation of pancreatic enzyme replacement therapy on residual function is necessary. Different tests with their advantages and disadvantages are critically reviewed in this article with respect to specificity, sensitivity, performance and cost-effectiveness. Conclusion Elastase-1 detection in faeces is probably the easiest test for the detection of pancreatic insufficiency in cystic fibrosis. For clinical follow-up tests, measuring the fat assimilation such as steatocrit and breath tests are more suited. Springer-Verlag Berlin Heidelberg, 2000 Key words Cystic fibrosis nationallicence Detection nationallicence Exocrine pancreatic insufficiency nationallicence Pancreatic function test nationallicence Screening nationallicence Leus Jasmine Ghent University Hospital, De Pintelaan 185, 8000 Ghent, Belgium, BE aut Van Biervliet Stéphanie Ghent University Hospital, De Pintelaan 185, 8000 Ghent, Belgium, BE aut Robberecht Eddy Ghent University Hospital, De Pintelaan 185, 8000 Ghent, Belgium, BE aut https://doi.org/10.1007/s004310000507 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310000507 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leus Jasmine Ghent University Hospital, De Pintelaan 185, 8000 Ghent, Belgium, BE aut NATIONALLICENCE 700 1- Van Biervliet Stéphanie Ghent University Hospital, De Pintelaan 185, 8000 Ghent, Belgium, BE aut NATIONALLICENCE 700 1- Robberecht Eddy Ghent University Hospital, De Pintelaan 185, 8000 Ghent, Belgium, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer