caa a22 4500 475786742 CHVBK 20180406123700.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004310051291 doi (NATIONALLICENCE)springer-10.1007/s004310051291 The effect of dexamethasone on growth, mineral balance and bone mineralisation in preterm infants with chronic lung disease [Elektronische Daten] [Anupam Shrivastava, Andrew Lyon, Neil McIntosh] The aim of this prospective longitudinal study was to observe the effects of treatment with dexamethasone on somatic growth, mineral balance and bone mineralisation in very low birth weight (VLBW) preterm infants with chronic lung disease (CLD). Dexamethasone was started at a dose of 500 μg/kg body weight per day for 3 days followed by gradually decreasing doses for a total period of 3 weeks' treatment if the infant was still mechanically ventilated in the 3rd postnatal week and had signs of CLD on the chest radiograph. Eleven infants with CLD treated with dexamethasone were studied. Administration of dexamethasone treatment was associated with significantly (P < 0.05) lower weight velocity, head circumference velocity, lower leg length (measured by the neonatal knemometer) velocity compared to pre-treatment changes. The start of dexamethasone treatment was also associated with a fall in calcium absorption (61% to 41.7%, P < 0.05) calcium retention (60.8% to 40.6%, P < 0.05) and phosphate retention (65% to 39.6%, P < 0.05); phosphate absorption was not significantly affected (88.8% to 92%, P > 0.05). Somatic growth and mineral balance improved during the immediate post-treatment period. Acute disturbances of bone mineral content (measured by dual energy radiographic densitometry), plasma calcium and phosphate were also seen but not reaching statistical significance at the P < 0.05 level. Conclusion The start of steroids is associated with a rapid and significant fall in growth velocity, calcium absorption and calcium and phosphate retention in infants with chronic lung disease with recovery occurring after completion of steroid treatment. Springer-Verlag Berlin Heidelberg, 2000 Key words Dexamethasone nationallicence Growth nationallicence Mineral balance nationallicence Preterm nationallicence Chronic lung disease nationallicence Shrivastava Anupam Department of Paediatrics, Southend General Hospital, Prittlewell Chase, Southend-on-Sea, Essex SS0 0RY, United Kingdom e-mail: anupam@shrivastava.freeserve.co.uk Tel.: +44-1702-221239; Fax: +44-1702-221252, GB aut Lyon Andrew Simpson Memorial Maternity Pavilion and Department of Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom, GB aut McIntosh Neil Simpson Memorial Maternity Pavilion and Department of Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom, GB aut https://doi.org/10.1007/s004310051291 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051291 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shrivastava Anupam Department of Paediatrics, Southend General Hospital, Prittlewell Chase, Southend-on-Sea, Essex SS0 0RY, United Kingdom e-mail: anupam@shrivastava.freeserve.co.uk Tel.: +44-1702-221239; Fax: +44-1702-221252, GB aut NATIONALLICENCE 700 1- Lyon Andrew Simpson Memorial Maternity Pavilion and Department of Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom, GB aut NATIONALLICENCE 700 1- McIntosh Neil Simpson Memorial Maternity Pavilion and Department of Child Life and Health, University of Edinburgh, Edinburgh, United Kingdom, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer