caa a22 4500 475786750 CHVBK 20180406123700.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004310051289 doi (NATIONALLICENCE)springer-10.1007/s004310051289 Final height, gonadal function and bone mineral density of adolescent males with central precocious puberty after therapy with gonadotropin-releasing hormone analogues [Elektronische Daten] [Silvano Bertelloni, Giampiero I. Baroncelli, Marco Ferdeghini, Fabrizio Menchini-Fabris, Giuseppe Saggese] Few data are available on the outcome of boys with central precocious puberty (CPP) treated with gonadotropin-releasing hormone (GnRH) analogues. We report on final height, endocrine and exocrine testicular function, and bone mineral density (BMD) in nine males (age 16.7 ± 1.5 years) treated with GnRH analogues from the age 6.0 ± 1.8 years for a mean period of 5.6 ± 2.4 years. The following parameters were evaluated: final height, serum gonadotropin and gonadal steroid levels, spermarche, semen analysis, area and volumetric BMD. Final height (−0.4 ± 1.1 SDS) was significantly higher than pre-treatment predicted adult height (−2.0 ± 1.2 SDS) and not significantly different than midparental height (−0.1 ± 0.8 SDS). Pubertal response of gonadotropins to GnRH test occurred within 1.5 years (mean 0.7 ± 0.4 years) and spermarche (n=7) from 0.7 to 3 years (1.8 ± 0.9 years) after the discontinuation of GnRH analogue therapy. No alteration in semen analysis was found (n=6, sperm count, 106/ml: 52.0 ± 18.7; normal motility (%): 49.5 ± 18.7; atypical morphology (%): 44.5 ± 11.4). Area and volumetric BMD were not reduced (0.2 ± 1.0 SDS and −0.1 ± 0.9 SDS, respectively). Conclusion Long-term treatment with gonadotropin-releasing hormone analogues improves final height in boys with central precocious puberty. Post-therapy data demonstrating normal endocrine and exocrine testicular function support the safety of gonadotropin-releasing hormone analogues on reproductive function. Long-term pharmacological suppression of testicular function in childhood does not impair bone mineral density in late adolescence. Springer-Verlag Berlin Heidelberg, 2000 Key words Central precocious puberty nationallicence Final height nationallicence Gonadotropin-releasing hormone analogues nationallicence Testicular function nationallicence Bone mineral density nationallicence Bertelloni Silvano II Division of Paediatrics, Santa Chiara Hospital, Via Roma, 67, 56125 Pisa, Italy Tel.: +39-050-592743; Fax: +39-050-550595, IT aut Baroncelli Giampiero I. Adolescent and Endocrine Units, Department of Reproductive Medicine and Paediatrics, II Division of Paediatrics, University of Pisa, "Santa Chiara” Hospital, Pisa, Italy, IT aut Ferdeghini Marco Dipartimento Scienze Morfologico-Biomediche Sezione di Radiologia, Universita di Verona, Verona, Italy, IT aut Menchini-Fabris Fabrizio Department of Reproductive Medicine and Paediatrics, Division of Andrology, University of Pisa, "Santa Chiara” Hospital, Pisa, Italy, IT aut Saggese Giuseppe Adolescent and Endocrine Units, Department of Reproductive Medicine and Paediatrics, II Division of Paediatrics, University of Pisa, "Santa Chiara” Hospital, Pisa, Italy, IT aut https://doi.org/10.1007/s004310051289 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051289 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bertelloni Silvano II Division of Paediatrics, Santa Chiara Hospital, Via Roma, 67, 56125 Pisa, Italy Tel.: +39-050-592743; Fax: +39-050-550595, IT aut NATIONALLICENCE 700 1- Baroncelli Giampiero I. Adolescent and Endocrine Units, Department of Reproductive Medicine and Paediatrics, II Division of Paediatrics, University of Pisa, "Santa Chiara” Hospital, Pisa, Italy, IT aut NATIONALLICENCE 700 1- Ferdeghini Marco Dipartimento Scienze Morfologico-Biomediche Sezione di Radiologia, Universita di Verona, Verona, Italy, IT aut NATIONALLICENCE 700 1- Menchini-Fabris Fabrizio Department of Reproductive Medicine and Paediatrics, Division of Andrology, University of Pisa, "Santa Chiara” Hospital, Pisa, Italy, IT aut NATIONALLICENCE 700 1- Saggese Giuseppe Adolescent and Endocrine Units, Department of Reproductive Medicine and Paediatrics, II Division of Paediatrics, University of Pisa, "Santa Chiara” Hospital, Pisa, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer