caa a22 4500 475786831 CHVBK 20180406123700.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004310051278 doi (NATIONALLICENCE)springer-10.1007/s004310051278 Auto-antibodies to the asialoglycoprotein receptor in sera of children with auto-immune hepatitis [Elektronische Daten] [O. Hajoui, D. Debray, S. Martin, F. Alvarez] Most studies on the prevalence of asialoglycoprotein antibodies have involved adults. In this study the prevalence of antibodies to the human asialoglycoprotein receptor (ASGP-R) was determined in 63 children with auto-immune hepatitis. It was shown that 75% of those with auto-immune hepatitis type 1 and 40% of those with auto-immune hepatitis type 2 were positive and the presence of anti-ASGP-R auto-antibodies, at a mean titre of 1:1,600 and 1:1,000 respectively. No statistical significance was found between anti-ASGP-R positive and negative patients with respect to the median age at onset, proportion of females and ALT levels. However, the titre of anti-ASGP-R antibodies correlated significantly with hypergammaglobulinaemia. Conclusion Anti-asialoglycoprotein receptor antibodies are frequently present in the sera of children with auto-immune hepatitis, particularly type 1, The presence of these antibodies is an indirect marker of inflammatory activity. Springer-Verlag Berlin Heidelberg, 2000 Key words Asialoglycoprotein receptor nationallicence LKM1 antibody nationallicence ELISA nationallicence Auto-immune hepatitis types 1 and 2 nationallicence Hypergammaglobulinaemia nationallicence Hajoui O. Service de Gastroentérologie, Hôpital Sainte-Justine, 3175, Côte Sainte-Catherine, Montreal, Quebec, H3 T 1C5 Canada e-mail: alvarez@ere.umontreal.ca Tel.: +1-514-345-4626; Fax: +1-514-345-4999, CA aut Debray D. Service d'Hépatologie Pediatrique, Hôpital de Bicêtre, Bicêtre, France, FR aut Martin S. Service de Gastroentérologie, Hôpital Sainte-Justine, 3175, Côte Sainte-Catherine, Montreal, Quebec, H3 T 1C5 Canada e-mail: alvarez@ere.umontreal.ca Tel.: +1-514-345-4626; Fax: +1-514-345-4999, CA aut Alvarez F. Service de Gastroentérologie, Hôpital Sainte-Justine, 3175, Côte Sainte-Catherine, Montreal, Quebec, H3 T 1C5 Canada e-mail: alvarez@ere.umontreal.ca Tel.: +1-514-345-4626; Fax: +1-514-345-4999, CA aut https://doi.org/10.1007/s004310051278 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051278 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hajoui O. Service de Gastroentérologie, Hôpital Sainte-Justine, 3175, Côte Sainte-Catherine, Montreal, Quebec, H3 T 1C5 Canada e-mail: alvarez@ere.umontreal.ca Tel.: +1-514-345-4626; Fax: +1-514-345-4999, CA aut NATIONALLICENCE 700 1- Debray D. Service d'Hépatologie Pediatrique, Hôpital de Bicêtre, Bicêtre, France, FR aut NATIONALLICENCE 700 1- Martin S. Service de Gastroentérologie, Hôpital Sainte-Justine, 3175, Côte Sainte-Catherine, Montreal, Quebec, H3 T 1C5 Canada e-mail: alvarez@ere.umontreal.ca Tel.: +1-514-345-4626; Fax: +1-514-345-4999, CA aut NATIONALLICENCE 700 1- Alvarez F. Service de Gastroentérologie, Hôpital Sainte-Justine, 3175, Côte Sainte-Catherine, Montreal, Quebec, H3 T 1C5 Canada e-mail: alvarez@ere.umontreal.ca Tel.: +1-514-345-4626; Fax: +1-514-345-4999, CA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer