caa a22 4500 47578684X CHVBK 20180406123700.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004310051288 doi (NATIONALLICENCE)springer-10.1007/s004310051288 Prophylactic ibuprofen therapy of patent ductus arteriosus in preterm infants [Elektronische Daten] [Maria Pia De Carolis, Constantino Romagnoli, Valentina Polimeni, Fiammetta Piersigilli, Enrico Zecca, Patrizia Papacci, Angelica Bibiana Delogu, Giuseppe Tortorolo] This study was aimed at evaluating the efficacy of ibuprofen in the prophylaxis of patent ductus arteriosus (PDA) in very preterm neonates and at detecting eventual side-effects. A total of 46 preterm neonates with gestational age under 31 weeks were randomly assigned at 2 h of life: 23 to the prophylaxis group and 23 to the control group. The prophylaxis group received intravenous treatment with ibuprofen lysine (10 mg/kg), followed by 5 mg/kg after 24 h and 48 h. No placebo was given to the control group. No PDA was demonstrated at 72 h of life in 20 of the 23 babies in the ibuprofen group (87%) nor in 7 of the 23 control neonates (30.4%). All neonates with PDA received treatment with indomethacin. One neonate in the prophylaxis group and three in the control group underwent surgical ligation. Prophylaxis with ibuprofen was not associated with any significant side-effect except for food intolerance. Conclusion Ibuprofen prophylaxis seems to be efficient in closing patent ductus arteriosus and in reducing indomethacin treatment. No significant early side-effects were found due to ibuprofen. Springer-Verlag Berlin Heidelberg, 2000 Key words Patent ductus arteriosus nationallicence Preterm neonates nationallicence Ibuprofen nationallicence Indomethacin nationallicence De Carolis Maria Pia Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut Romagnoli Constantino Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut Polimeni Valentina Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut Piersigilli Fiammetta Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut Zecca Enrico Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut Papacci Patrizia Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut Delogu Angelica Bibiana Division of Paediatric Cardiology, Catholic University of the Sacred Heart, Rome, Italy, IT aut Tortorolo Giuseppe Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut https://doi.org/10.1007/s004310051288 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051288 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Carolis Maria Pia Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut NATIONALLICENCE 700 1- Romagnoli Constantino Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut NATIONALLICENCE 700 1- Polimeni Valentina Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut NATIONALLICENCE 700 1- Piersigilli Fiammetta Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut NATIONALLICENCE 700 1- Zecca Enrico Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut NATIONALLICENCE 700 1- Papacci Patrizia Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut NATIONALLICENCE 700 1- Delogu Angelica Bibiana Division of Paediatric Cardiology, Catholic University of the Sacred Heart, Rome, Italy, IT aut NATIONALLICENCE 700 1- Tortorolo Giuseppe Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Largo A. Gemelli 8,00168 Rome, Italy e-mail: iclpe@rm.unicatt.it Tel.: +39-6-30154357/3053730; Fax: +39-6-3051343, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer