caa a22 4500 475786874 CHVBK 20180406123700.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004310051285 doi (NATIONALLICENCE)springer-10.1007/s004310051285 Growth, puberty and hypothalamic-pituitary function in children with suprasellar arachnoid cyst [Elektronische Daten] [Luis Adan, Laurence Bussières, Véronique Dinand, Michel Zerah, Alain Pierre-Kahn, Raja Brauner] A suprasellar arachnoid cyst may cause disorders of growth, puberty and hypothalamic-pituitary function, due to the proximity of the cyst to the hypothalamic-pituitary area. A total of 30 patients (17 boys) with cyst diagnosed at 4.3 ± 1 years were routinely evaluated at 5.4 ± 1 years; 24 of them had one or multiple cyst derivations. Some 23 cases had an abnormal height, weight or puberty: short (<−2SD, 5 cases) or tall (>2SD, 10 cases) stature, overweight (body mass index, BMI, >2SD, 6 cases), central precocious puberty (10 cases) and/or no progression of pubertal development (3 cases). The growth hormone (GH) peaks after pharmacological stimulation test were low (<10 μg/l) in 16 patients, confirmed by a second evaluation in 8/11 of them. The plasma free thyroxine was low in five patients, prolactin was high in two and the cortisol and concomitant plasma and urinary osmolalities were normal. BMI was correlated negatively with the GH peaks (r=−0.37, P < 0.01) and positively with the plasma leptin concentrations (r=0.55, P < 0.01). The plasma fasting insulin concentrations were also correlated negatively with the GH peaks (r=−0.55, P < 0.02) and positively with the plasma insulin-like growth factor I concentrations (r=0.64, P < 0.002). The adult height (12 cases) was at 4SD in 1 and <−2SD in 4 patients, two of whom had precocious puberty untreated with gonadotropin releasing hormone (GnRH) analogue, and two had untreated GH deficiency. The adult height of those treated was normal. One girl had primary amenorrhoea and two boys had low plasma testosterone, despite a normal gonadotropin response to a GnRH test. Conclusion Suprasellar arachnoid cysts may cause deficiencies of growth hormone and thyrotropin, stimulation of the hypothalamic-pituitary-gonadal axis, tall stature and/or overweight. These last two disorders may be due to hyperinsulinism, itself due to suprasellar arachnoid cyst. Springer-Verlag Berlin Heidelberg, 2000 Key words Arachnoid cyst nationallicence Growth nationallicence Growth hormone deficiency nationallicence Growth hormone treatment nationallicence Insulin nationallicence Leptin nationallicence Puberty nationallicence Precocious puberty nationallicence Adan Luis Department of Paediatric Endocrinology, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75743 Paris Cedex 15, France e-mail: raja.brauner@wanadoo.fr Tel.: +33-1-44494803; Fax: +33-1-44381648, FR aut Bussières Laurence Physiology Laboratory, Université René Descartes and Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, FR aut Dinand Véronique Department of Paediatric Endocrinology, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75743 Paris Cedex 15, France e-mail: raja.brauner@wanadoo.fr Tel.: +33-1-44494803; Fax: +33-1-44381648, FR aut Zerah Michel Department of Neurosurgery, Université René Descartes and Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, FR aut Pierre-Kahn Alain Department of Neurosurgery, Université René Descartes and Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, FR aut Brauner Raja Department of Paediatric Endocrinology, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75743 Paris Cedex 15, France e-mail: raja.brauner@wanadoo.fr Tel.: +33-1-44494803; Fax: +33-1-44381648, FR aut https://doi.org/10.1007/s004310051285 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051285 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Adan Luis Department of Paediatric Endocrinology, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75743 Paris Cedex 15, France e-mail: raja.brauner@wanadoo.fr Tel.: +33-1-44494803; Fax: +33-1-44381648, FR aut NATIONALLICENCE 700 1- Bussières Laurence Physiology Laboratory, Université René Descartes and Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, FR aut NATIONALLICENCE 700 1- Dinand Véronique Department of Paediatric Endocrinology, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75743 Paris Cedex 15, France e-mail: raja.brauner@wanadoo.fr Tel.: +33-1-44494803; Fax: +33-1-44381648, FR aut NATIONALLICENCE 700 1- Zerah Michel Department of Neurosurgery, Université René Descartes and Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, FR aut NATIONALLICENCE 700 1- Pierre-Kahn Alain Department of Neurosurgery, Université René Descartes and Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, FR aut NATIONALLICENCE 700 1- Brauner Raja Department of Paediatric Endocrinology, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75743 Paris Cedex 15, France e-mail: raja.brauner@wanadoo.fr Tel.: +33-1-44494803; Fax: +33-1-44381648, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer