caa a22 4500 47578717X CHVBK 20180406123701.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/PL00008354 doi (NATIONALLICENCE)springer-10.1007/PL00008354 Neonatal respiratory distress syndrome - a sign of primary ciliary dyskinesia? [Elektronische Daten] [David Holzmann, Heidi Felix] Primary ciliary dyskinesia (PCD) is a clinically heterogeneous disease. In most cases, its clinical manifestation in children is rather unspecific: chronic infectious rhinosinusitis, recurrent acute infections of the upper and lower airways and chronic otitis media with effusion. Between 1990 and 1998 ten patients were diagnosed as PCD. Nine presented a neonatal respiratory distress syndrome (NRDS) of unknown cause. Six of these patients were newborns treated in the intensive care unit, one of them needed mechanical ventilation. The few cases already described in the literature and the experience with our patients support the possible association of NRDS with PCD. Conclusion Neonatal respiratory distress syndrome of unknown cause should be added to the list of clinical presentation of primary ciliary dyskinesia, and if further signs and symptoms are indicative of primary ciliary dyskinesia, investigations to explore this disorder are warranted. Springer-Verlag Berlin Heidelberg, 2000 Key words Ciliary dyskinesia nationallicence Infant nationallicence Respiratory distress syndrome nationallicence Respiratory tract infections nationallicence AbbreviationsNRDS neonatal respiratory distress syndrome nationallicence OME otitis media with effusion nationallicence PCD primary ciliary dyskinesia nationallicence Holzmann David Department of Otorhinolaryngology Head and Neck Surgery, University Hospital, Frauenklinikstrasse 24, 8091 Zurich, Switzerland e-mail: holzmann@orl.usz.ch Tel.: +41-1-2555860; Fax: +41-1-2554556, CH aut Felix Heidi Department of Otorhinolaryngology Head and Neck Surgery, University Hospital, Frauenklinikstrasse 24, 8091 Zurich, Switzerland e-mail: holzmann@orl.usz.ch Tel.: +41-1-2555860; Fax: +41-1-2554556, CH aut https://doi.org/10.1007/PL00008354 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008354 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holzmann David Department of Otorhinolaryngology Head and Neck Surgery, University Hospital, Frauenklinikstrasse 24, 8091 Zurich, Switzerland e-mail: holzmann@orl.usz.ch Tel.: +41-1-2555860; Fax: +41-1-2554556, CH aut NATIONALLICENCE 700 1- Felix Heidi Department of Otorhinolaryngology Head and Neck Surgery, University Hospital, Frauenklinikstrasse 24, 8091 Zurich, Switzerland e-mail: holzmann@orl.usz.ch Tel.: +41-1-2555860; Fax: +41-1-2554556, CH aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer