caa a22 4500 475787390 CHVBK 20180406123702.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s004140000141 doi (NATIONALLICENCE)springer-10.1007/s004140000141 Postmortem absorption of dichloromethane: a case study and animal experiments [Elektronische Daten] [H. Takeshita, K. Mogi, T. Yasuda, S. Mori, Y. Nakashima, T. Nakajima, H. Akuzawa, S. Nakajo, Y. Hirota, K. Kishi] A case of accidental death after occupational exposure to an atmosphere containing dichloromethane (DCM) is reported. The concentrations of DCM in the blood and tissues of a 40-year-old man who died while observing an industrial washing machine filled with DCM vapour were blood 1660 mg/l, urine 247 mg/l, brain 87 mg/ kg, heart muscle 199 mg/kg and lungs 103 mg/kg which are 3-7 times higher than previously reported fatal levels. The body was left undiscovered in the machine filled with DCM vapour for about 20 h. The present study was designed to determine whether all the DCM detected in the tissues and body fluids had been inhaled while alive using rats as the experimental model. The concentrations of DCM in the tissues and body fluids of a rat that died from DCM poisoning and was left for 20 h in a box containing DCM vapour were the same as those in the tissues and body fluids of a rat that had died from an injected overdose of barbiturates and had then been placed in the DCM box in a similar manner. Moreover, the concentrations of DCM in the tissues and body fluids of the carcasses that were exposed to the DCM vapour increased gradually throughout the period of exposure. These findings imply that DCM is able to penetrate the tissues and body fluids of rat carcasses through a route other than inhalation such as through the skin. Springer-Verlag Berlin Heidelberg, 2000 Key words Blood nationallicence Dichloromethane nationallicence Poisoning nationallicence Postmortem change nationallicence Tissue nationallicence Takeshita H. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut Mogi K. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut Yasuda T. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut Mori S. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut Nakashima Y. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut Nakajima T. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut Akuzawa H. Criminal Investigation Laboratory, Gunma Prefectural Police Headquarters, Maebashi, Gunma, 371-0846 Japan, JP aut Nakajo S. Criminal Investigation Department, Gunma Prefectural Police Headquarters, Maebashi, Gunma, 371-8580 Japan, JP aut Hirota Y. Criminal Investigation Department, Gunma Prefectural Police Headquarters, Maebashi, Gunma, 371-8580 Japan, JP aut Kishi K. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut https://doi.org/10.1007/s004140000141 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004140000141 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takeshita H. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut NATIONALLICENCE 700 1- Mogi K. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut NATIONALLICENCE 700 1- Yasuda T. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut NATIONALLICENCE 700 1- Mori S. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut NATIONALLICENCE 700 1- Nakashima Y. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut NATIONALLICENCE 700 1- Nakajima T. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut NATIONALLICENCE 700 1- Akuzawa H. Criminal Investigation Laboratory, Gunma Prefectural Police Headquarters, Maebashi, Gunma, 371-0846 Japan, JP aut NATIONALLICENCE 700 1- Nakajo S. Criminal Investigation Department, Gunma Prefectural Police Headquarters, Maebashi, Gunma, 371-8580 Japan, JP aut NATIONALLICENCE 700 1- Hirota Y. Criminal Investigation Department, Gunma Prefectural Police Headquarters, Maebashi, Gunma, 371-8580 Japan, JP aut NATIONALLICENCE 700 1- Kishi K. Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Gunma, 371-8511 Japan e-mail: kkoichi@med.gunma-u.ac.jp; Tel.: +81-27-2208034; Fax: +81-27-2208035, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer