caa a22 4500 475787544 CHVBK 20180406123703.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s004140000133 doi (NATIONALLICENCE)springer-10.1007/s004140000133 The distribution of laudanosine in tissues after death from atracurium injection [Elektronische Daten] [P. Kintz, A. Tracqui, B. Ludes] A case is presented involving an acute fatality resulting from self-administration of atracurium, a muscle relaxant by a 45-year-old nurse. In the body, atracurium undergoes a spontaneous non-enzymatic degradation to laudanosine and an acrylate moiety. Laudanosine was quantified using gas chromatography coupled to mass spectrometry after extraction with chloroform-isopropanol-n-heptane (50 : 17 : 33 v/v) at pH 9.5 and separation on a HP5-MS capillary column. Laudanosine was subject to postmortem redistribution due to release from drug-rich tissues such as the lung and heart. The heart blood (917 ng/ml) to peripheral blood (390 ng/ml) ratio was 2.4. No other drugs, including ethanol were detected. Springer-Verlag Berlin Heidelberg, 2000 Key words Atracurium nationallicence Laudanosine nationallicence Fatality nationallicence Postmortem redistribution nationallicence Kintz P. Institut de Médecine Légale, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France e-mail: pascal.kintz@wanadoo.fr; Fax: +33-3-8240085, FR aut Tracqui A. Institut de Médecine Légale, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France e-mail: pascal.kintz@wanadoo.fr; Fax: +33-3-8240085, FR aut Ludes B. Institut de Médecine Légale, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France e-mail: pascal.kintz@wanadoo.fr; Fax: +33-3-8240085, FR aut https://doi.org/10.1007/s004140000133 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004140000133 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kintz P. Institut de Médecine Légale, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France e-mail: pascal.kintz@wanadoo.fr; Fax: +33-3-8240085, FR aut NATIONALLICENCE 700 1- Tracqui A. Institut de Médecine Légale, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France e-mail: pascal.kintz@wanadoo.fr; Fax: +33-3-8240085, FR aut NATIONALLICENCE 700 1- Ludes B. Institut de Médecine Légale, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg Cedex, France e-mail: pascal.kintz@wanadoo.fr; Fax: +33-3-8240085, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer