caa a22 4500 475787552 CHVBK 20180406123703.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s004140000135 doi (NATIONALLICENCE)springer-10.1007/s004140000135 Is vitreous humour useful for the interpretation of 3,4-methylenedioxymethamphetamine (MDMA) blood levels? [Elektronische Daten] Experimental approach with rabbits [E. A. De Letter, P. De Paepe, K. M. Clauwaert, F. M. Belpaire, W. E. Lambert, J. F. Van Bocxlaer, M. H. A. Piette] As drug instability and redistribution are factors known to affect the interpretation of post-mortem blood levels, we questioned whether post-mortem vitreous humour concentrations could be useful as predictors for the MDMA load at the time of death. In a first series of in vivo experiments using rabbits, 3,4-methylenedioxy-methamphetamine (MDMA) concentrations in plasma, blood and vitreous humour were studied as a function of time after intravenous (iv) administration of MDMA. Equilibration between the vascular compartment and vitreous humour was attained about 1 h after iv MDMA administration. In a second series of experiments, the post-mortem stability of MDMA in vitreous humour in relation to ambient temperature was investigated. Post-mortem MDMA concentrations in vitreous humour were closer to the ante-mortem blood levels when compared to cardiac blood samples. These preliminary investigations in the rabbit model indicate that measurements of vitreous humour concentrations could also be of interest for predicting the blood concentration at the time of death in humans. Springer-Verlag Berlin Heidelberg, 2000 Key words 3 nationallicence 4-Methylenedioxymethamphetamine nationallicence MDMA nationallicence Vitreous humour nationallicence Pharmacokinetics nationallicence Post-mortem stability nationallicence Rabbits nationallicence De Letter E. A. Department of Forensic Medicine, Ghent University, J. Kluyskensstraat 29, 9000 Ghent, Belgium e-mail: Michel.Piette@rug.ac.be; Tel.: +32-9-2649291; Fax: +32-9-2649495, BE aut De Paepe P. Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium, BE aut Clauwaert K. M. Department of Toxicology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium, BE aut Belpaire F. M. Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium, BE aut Lambert W. E. Department of Toxicology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium, BE aut Van Bocxlaer J. F. Department of Toxicology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium, BE aut Piette M. H. A. Department of Forensic Medicine, Ghent University, J. Kluyskensstraat 29, 9000 Ghent, Belgium e-mail: Michel.Piette@rug.ac.be; Tel.: +32-9-2649291; Fax: +32-9-2649495, BE aut https://doi.org/10.1007/s004140000135 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004140000135 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Letter E. A. Department of Forensic Medicine, Ghent University, J. Kluyskensstraat 29, 9000 Ghent, Belgium e-mail: Michel.Piette@rug.ac.be; Tel.: +32-9-2649291; Fax: +32-9-2649495, BE aut NATIONALLICENCE 700 1- De Paepe P. Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium, BE aut NATIONALLICENCE 700 1- Clauwaert K. M. Department of Toxicology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium, BE aut NATIONALLICENCE 700 1- Belpaire F. M. Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium, BE aut NATIONALLICENCE 700 1- Lambert W. E. Department of Toxicology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium, BE aut NATIONALLICENCE 700 1- Van Bocxlaer J. F. Department of Toxicology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium, BE aut NATIONALLICENCE 700 1- Piette M. H. A. Department of Forensic Medicine, Ghent University, J. Kluyskensstraat 29, 9000 Ghent, Belgium e-mail: Michel.Piette@rug.ac.be; Tel.: +32-9-2649291; Fax: +32-9-2649495, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer