caa a22 4500 475787749 CHVBK 20180406123703.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004140050292 doi (NATIONALLICENCE)springer-10.1007/s004140050292 Acute intoxication with aniline: detection of acetaminophen as aniline metabolite [Elektronische Daten] [S. Iwersen-Bergmann, A. Schmoldt] A 47-year-old woman unwittingly ingested an unknown substance together with her breakfast coffee. She suffered effects such as strong headache, generalized cyanosis, and a burning sensation of the lips and collapsed some minutes later. After admission into hospital a methemoglobin level of 35% was determined in the blood. Treatment by administration of tolonium chloride (toluidine blue) resulted in complete recovery of the patient. The toxic agent was identified as aniline by GC with mass selective detection after organic solvent extraction and 11 h after ingestion the plasma aniline level was 0.13 mg/l. Acetanilide (0.79 mg/ml) and acetaminophen (2.3 mg/ml) were identified in plasma as metabolites of aniline. It was assumed that a high metabolic capacity for acetylation protected the victim from more severe reactions. Her husband confessed later that he had tried to poison her. Springer-Verlag Berlin Heidelberg, 2000 Key words Aniline nationallicence Poisoning nationallicence Plasma level nationallicence Metabolism nationallicence Iwersen-Bergmann S. Department of Legal Medicine, University of Hamburg, Butenfeld 34, D-22529 Hamburg, Germany, DE aut Schmoldt A. Department of Legal Medicine, University of Hamburg, Butenfeld 34, D-22529 Hamburg, Germany, DE aut https://doi.org/10.1007/s004140050292 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004140050292 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iwersen-Bergmann S. Department of Legal Medicine, University of Hamburg, Butenfeld 34, D-22529 Hamburg, Germany, DE aut NATIONALLICENCE 700 1- Schmoldt A. Department of Legal Medicine, University of Hamburg, Butenfeld 34, D-22529 Hamburg, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer