caa a22 4500 475787781 CHVBK 20180406123704.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004140050284 doi (NATIONALLICENCE)springer-10.1007/s004140050284 Cannabinoid mimics in chocolate utilized as an argument in court [Elektronische Daten] [J. Tytgat, M. Van Boven, P. Daenens] A case is presented involving chocolate cannabinoid mimics which have been utilized in court by the defendant's lawyer in order to clear the accused of smoking and dealing in marijuana after he was found positive for cannabis in a routine urine immunoassay screening test. The argumentation in this case was that the accused had supposedly eaten a massive amount of chocolate which contained anandamide-related lipids. These lipids inhibit anandamide hydrolysis in the brain, act as cannabinoid mimics and, according to the lawyer, were the cause of the positive cannabinoid test. To investigate this in detail, we synthesized N-oleoyl- and N-linoleoylethanolamide and spiked these compounds together with N-arachidonoylethanolamide in urine for immunological investigations. None of the samples were found positive, indicating that no cross-reactivity occurs with cannabinoids. As a result, the lawyer's claim could be refuted and the accused was convicted. Springer-Verlag Berlin Heidelberg, 2000 Key words Cannabinoid nationallicence Chocolate nationallicence Immunoassay nationallicence Anandamide nationallicence N-Acylethanolamide nationallicence Tytgat J. Laboratory of Toxicology, E. Van Evenstraat 4, B-3000 Leuven, Belgium e-mail: jan.tytgat@farm.kuleuven.ac.be, Tel. +32-16-323403, Fax +32-16-323405, BE aut Van Boven M. Laboratory of Toxicology, E. Van Evenstraat 4, B-3000 Leuven, Belgium e-mail: jan.tytgat@farm.kuleuven.ac.be, Tel. +32-16-323403, Fax +32-16-323405, BE aut Daenens P. Laboratory of Toxicology, E. Van Evenstraat 4, B-3000 Leuven, Belgium e-mail: jan.tytgat@farm.kuleuven.ac.be, Tel. +32-16-323403, Fax +32-16-323405, BE aut https://doi.org/10.1007/s004140050284 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004140050284 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tytgat J. Laboratory of Toxicology, E. Van Evenstraat 4, B-3000 Leuven, Belgium e-mail: jan.tytgat@farm.kuleuven.ac.be, Tel. +32-16-323403, Fax +32-16-323405, BE aut NATIONALLICENCE 700 1- Van Boven M. Laboratory of Toxicology, E. Van Evenstraat 4, B-3000 Leuven, Belgium e-mail: jan.tytgat@farm.kuleuven.ac.be, Tel. +32-16-323403, Fax +32-16-323405, BE aut NATIONALLICENCE 700 1- Daenens P. Laboratory of Toxicology, E. Van Evenstraat 4, B-3000 Leuven, Belgium e-mail: jan.tytgat@farm.kuleuven.ac.be, Tel. +32-16-323403, Fax +32-16-323405, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer