caa a22 4500 475787811 CHVBK 20180406123704.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s004149900094 doi (NATIONALLICENCE)springer-10.1007/s004149900094 A comparative study on the immunohistochemical detection of early myocardial damage [Elektronische Daten] [C. Ortmann, H. Pfeiffer, B. Brinkmann] The study was undertaken to evaluate the kinetics and distribution patterns of several immunohistochemical markers in ischemically and hypoxically damaged myocardium. The myocardium of 8 cases of acute myocardial infarction (AMI), 8 cases of diagnosed acute cardiac death (ACD) and 12 cases of acute exogenic hypoxia (AEH) due to CO poisoning or hanging were analysed for depletion of the cardiac antigens FABP, troponin C and T, desmin and myoglobin, loss of CD59 and deposition of the plasma antigens fibrinogen, fibronectin and the terminal complement complex C5b-9. The visualisation of the terminal complement complex was positive as early as 30 min after onset of symptoms of AMI. Depletion of cellular antigens started earlier than the deposition of plasma antigens. The deposition of fibronectin and fibrinogen began earlier than the detection of C5b-9 but later than the depletion of the cellular antigens. Our findings indicate that for the immunohistochemical detection of very early myocardial damage, the depletion of myoglobin is at least of the same rank or better than depletion of FABP and troponin. Springer-Verlag Berlin Heidelberg, 2000 Key words FABP nationallicence Troponin nationallicence Myoglobin nationallicence Fibronectin nationallicence Myocardial infarction nationallicence Ortmann C. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, D-48129 Münster, Germany Fax: +49-251-8355158, DE aut Pfeiffer H. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, D-48129 Münster, Germany Fax: +49-251-8355158, DE aut Brinkmann B. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, D-48129 Münster, Germany Fax: +49-251-8355158, DE aut https://doi.org/10.1007/s004149900094 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004149900094 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ortmann C. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, D-48129 Münster, Germany Fax: +49-251-8355158, DE aut NATIONALLICENCE 700 1- Pfeiffer H. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, D-48129 Münster, Germany Fax: +49-251-8355158, DE aut NATIONALLICENCE 700 1- Brinkmann B. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, D-48129 Münster, Germany Fax: +49-251-8355158, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer