caa a22 4500 475787943 CHVBK 20180406123704.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004149900128 doi (NATIONALLICENCE)springer-10.1007/s004149900128 ROC analysis of alcoholism markers - 100% specificity [Elektronische Daten] [B. Brinkmann, H. Köhler, S. Banaschak, A. Berg, B. Eikelmann, A. West, A. Heinecke] A combination of 4 so-called markers of alcoholism, i. e. methanol, aceton + 2-propanol, γ-glutamyl-transferase and carbohydrate deficient transferrin, was investigated in 341 blood samples from alcoholics and non-alcoholics. From the history of alcohol consumption, four defined subgroups were formed: non-alcoholics divided into (A) 33 persons with no ethanol consumption during the past year and (B) 60 persons with daily consumption less then 40 g ethanol. Alcoholics were divided into (C) 177 persons with no ethanol at the time of admission/first blood sampling (withdrawal therapy) and (D) 71 persons with positive ethanol levels on admission/first blood sampling. All markers showed different extents of overlap between the collectives of alcoholics and non-alcoholics. By logistic regression, a formula was developed combining these markers with different mathematical weights. Thus an "Alc-Index” could be calculated for each individual. The ROC curve connecting all individual values gives an ideal form with 100% specificity and nearly 93% sensitivity. The threshold between the collectives of alcoholics and non-alcoholics was defined by the Alc-Index value 1.7. This was associated with no false positives among the non-alcoholics while nearly 93% of the alcoholics exceeded this index. The ROC-based calculation of the Alc-Index thus seems to be the most effective method for the diagnosis of alcoholism. Springer-Verlag Berlin Heidelberg, 2000 Key words Alcoholism nationallicence Biological markers nationallicence ROC-analysis nationallicence Specificity nationallicence Sensitivity nationallicence Brinkmann B. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48149 Münster, Germany, DE aut Köhler H. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48149 Münster, Germany, DE aut Banaschak S. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48149 Münster, Germany, DE aut Berg A. Westfälische Klinik für Psychiatrie und Psychotherapie, Friedrich-Wilhelm-Weber-Strasse 30, 48147 Münster, Germany, DE aut Eikelmann B. Westfälische Klinik für Psychiatrie und Psychotherapie, Friedrich-Wilhelm-Weber-Strasse 30, 48147 Münster, Germany, DE aut West A. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48149 Münster, Germany, DE aut Heinecke A. Institut für Medizinische Informatik und Biomathematik, Domagstrasse 9, 48149 Münster, Germany, DE aut https://doi.org/10.1007/s004149900128 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004149900128 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brinkmann B. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48149 Münster, Germany, DE aut NATIONALLICENCE 700 1- Köhler H. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48149 Münster, Germany, DE aut NATIONALLICENCE 700 1- Banaschak S. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48149 Münster, Germany, DE aut NATIONALLICENCE 700 1- Berg A. Westfälische Klinik für Psychiatrie und Psychotherapie, Friedrich-Wilhelm-Weber-Strasse 30, 48147 Münster, Germany, DE aut NATIONALLICENCE 700 1- Eikelmann B. Westfälische Klinik für Psychiatrie und Psychotherapie, Friedrich-Wilhelm-Weber-Strasse 30, 48147 Münster, Germany, DE aut NATIONALLICENCE 700 1- West A. Institut für Rechtsmedizin, Westfälische Wilhelms-Universität, Von-Esmarch-Strasse 62, 48149 Münster, Germany, DE aut NATIONALLICENCE 700 1- Heinecke A. Institut für Medizinische Informatik und Biomathematik, Domagstrasse 9, 48149 Münster, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer