caa a22 4500 47578796X CHVBK 20180406123704.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004149900114 doi (NATIONALLICENCE)springer-10.1007/s004149900114 Myocardial findings in fatal carbon monoxide poisoning: a human and experimental morphometric study [Elektronische Daten] [V. Fineschi, E. Agricola, G. Baroldi, G. Bruni, D. Cerretani, S. Mondillo, M. Parolini, E. Turillazzi] The aim of this study was to define the status of the myocardium in selected human cases of acute, fatal carbon monoxide intoxication and the myocardial changes in rats exposed to carbon monoxide in relation to the type of cardiac arrest and the effects of reoxygenation following pre-fatal CO intoxication. The human study consisted of 26 cases (17 accidental and 9 suicide) of acute, fatal CO intoxication, without evidence of obstructive coronary atherosclerosis or history of ischemic heart disease which were compared with 45 cases of fatal head trauma in subjects who died instantaneously (26 cases) or within 1-12 h (19 cases). Inhalation of a lethal dose of CO in rats was compared with sub-lethal doses plus reoxygenation with and without pre-treatment by a betablocker. In all human and experimental histological sections, changes were normalised per mm2 area. In the human cases the myocardium did not show any ischemic types of changes or other lesions. Only in "three accidental” cases a few, small foci of coagulative myocytolysis were detected. In the case of spontaneous death in 31 rats following CO intoxication, no pathological myocardial changes were seen. Of the 15 "reoxygenated” rats, 2 of the 7 spontaneous deaths presented coagulative myocytolysis with 15 ± 6 foci and 381 ± 255 necrotic myocells. All the eight rats sacrificed at 3 h had coagulative myocytolysis with 5 ± 4 foci and ¶60 ± 47 myocells. Of the 24 reoxygenated rats pre-treated with a betablocker, 5 died spontaneously after a short survival and 2 of these showed 11 ± 9 foci and 21 ± 20 myocells. The 19 rats sacrificed after 3 h all presented coagulative myocytolysis with figures of 75 ± 43 and ¶356 ± 301 with 0.5 mg/kg of propranolol hydrochloride and 55 ± 45 and 253 ± 216 with 2 mg/kg, respectively. Springer-Verlag Berlin Heidelberg, 2000 Key words Carbon monoxide poisoning nationallicence Acute ¶toxicity nationallicence Myocardial necrosis nationallicence Catecolamine ¶myotoxicity nationallicence Coagulative myocytolysis nationallicence Fineschi V. Division of Legal Medicine, University of Foggia, Ospedali Riuniti, Via L. Pinto, I-71100 Foggia, Italy, IT aut Agricola E. Institute of Cardiology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy, IT aut Baroldi G. Institute of Clinical Physiology, National Research Council, Department of Cardiology "De Gasperis”, Niguarda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy, IT aut Bruni G. Institute of Pharmacology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy, IT aut Cerretani D. Institute of Pharmacology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy, IT aut Mondillo S. Institute of Cardiology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy, IT aut Parolini M. Institute of Clinical Physiology, National Research Council, Department of Cardiology "De Gasperis”, Niguarda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy, IT aut Turillazzi E. Division of Legal Medicine, University of Foggia, Ospedali Riuniti, Via L. Pinto, I-71100 Foggia, Italy, IT aut https://doi.org/10.1007/s004149900114 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004149900114 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fineschi V. Division of Legal Medicine, University of Foggia, Ospedali Riuniti, Via L. Pinto, I-71100 Foggia, Italy, IT aut NATIONALLICENCE 700 1- Agricola E. Institute of Cardiology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy, IT aut NATIONALLICENCE 700 1- Baroldi G. Institute of Clinical Physiology, National Research Council, Department of Cardiology "De Gasperis”, Niguarda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy, IT aut NATIONALLICENCE 700 1- Bruni G. Institute of Pharmacology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy, IT aut NATIONALLICENCE 700 1- Cerretani D. Institute of Pharmacology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy, IT aut NATIONALLICENCE 700 1- Mondillo S. Institute of Cardiology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy, IT aut NATIONALLICENCE 700 1- Parolini M. Institute of Clinical Physiology, National Research Council, Department of Cardiology "De Gasperis”, Niguarda Hospital, Piazza Ospedale Maggiore 3, 20162 Milan, Italy, IT aut NATIONALLICENCE 700 1- Turillazzi E. Division of Legal Medicine, University of Foggia, Ospedali Riuniti, Via L. Pinto, I-71100 Foggia, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer