caa a22 4500 475788001 CHVBK 20180406123704.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004149900126 doi (NATIONALLICENCE)springer-10.1007/s004149900126 The time course of the vascular response to human brain injury - an immunohistochemical study [Elektronische Daten] [R. Hausmann, P. Betz] In a total of 104 individuals who had sustained traumatic brain injury (TBI), the time-dependent vascular response was investigated at the injured cortical area during the first 30 weeks after the trauma. The immunohistochemical staining of the cerebral blood vessels was performed with antibodies against laminin, type IV collagen, tenascin, thrombomodulin and factor VIII associated antigen. Compared to the immunoreactivity in unaltered control tissue, a significantly increased vascular expression could be detected in cortical contusions after a postinfliction interval of at least 3 h for factor VIII, after 1.6 days for tenascin or after 6.8 days for thrombomodulin, whereas the immunostaining for laminin and type IV collagen was regularly positive even in the vascular endothelium of uninjured brain tissue. Springer-Verlag Berlin Heidelberg, 2000 Key words Brain injury nationallicence Cortical contusion nationallicence Vascular ¶reaction nationallicence Immunohistochemistry nationallicence Wound age nationallicence Hausmann R. Department of Legal Medicine, University of Erlangen-Nürnberg, Universitätsstrasse 22, 91054 Erlangen, Germany, DE aut Betz P. Department of Legal Medicine, University of Erlangen-Nürnberg, Universitätsstrasse 22, 91054 Erlangen, Germany, DE aut https://doi.org/10.1007/s004149900126 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004149900126 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hausmann R. Department of Legal Medicine, University of Erlangen-Nürnberg, Universitätsstrasse 22, 91054 Erlangen, Germany, DE aut NATIONALLICENCE 700 1- Betz P. Department of Legal Medicine, University of Erlangen-Nürnberg, Universitätsstrasse 22, 91054 Erlangen, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer