caa a22 4500 475790464 CHVBK 20180406123709.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s004230050002 doi (NATIONALLICENCE)springer-10.1007/s004230050002 Inflammatory response after laparoscopic and conventional colorectal resections - results of a prospective randomized trial [Elektronische Daten] [W. Schwenk, C. Jacobi, U. Mansmann, B. Böhm, J. M. Müller] Abstract : Background: Short-term benefits of laparoscopic relative to conventional colorectal resections have been demonstrated in randomized controlled trials. It has been suggested that a diminished cytokine and acute-phase response may be responsible for these advantages. Methods: In a randomized controlled trial, patients underwent laparoscopic (n=30) or conventional (n=30) resection of colorectal tumors. Plasma levels of interleukin-1 receptor antagonist (IL-1RA), interleukin-6 (IL-6), interleukin-10 (IL-10), and C-reactive protein (CRP) were analyzed repeatedly. Postoperative peak levels and area under the curve values were calculated and compared between groups using the Mann-Whitney U-test. Results: Patient characteristics, preoperative cytokine, and CRP plasma levels were not different between each group. Postoperative peak concentrations of IL-6 (P=0.05) and CRP (P<0.001) and the overall postoperative plasma concentrations of IL-6 (P=0.03) and CRP (P=0.002) were lower in the laparoscopic than in the conventional group. Peak and overall IL-1RA (P=0.2; P=0.2) and IL-10 (P=0.4; P=0.6) plasma concentrations, respectively, were not different between groups. Conclusions: IL-6 and CRP plasma levels were lower after laparoscopic than conventional colorectal resections. The less intense inflammatory response may be an indicator of the milder surgical trauma inflicted by laparoscopic than conventional colorectal resection. Springer-Verlag Berlin Heidelberg, 2000 Key words Colorectal resections nationallicence Laparoscopic surgery nationallicence Cytokines nationallicence Acute-phase reaction nationallicence Schwenk W. Department of General, Visceral, Vascular and Thoracic Surgery, Benjamin Franklin Medical School, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Schumannstr. 20/21, D-10117l Berlin, Germany, e-mail: schwenk@charite.de, Tel.: +49-30-28025048, Fax: +49-30-28021175, DE aut Jacobi C. Department of General, Visceral, Vascular and Thoracic Surgery, Benjamin Franklin Medical School, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Schumannstr. 20/21, D-10117l Berlin, Germany, e-mail: schwenk@charite.de, Tel.: +49-30-28025048, Fax: +49-30-28021175, DE aut Mansmann U. Institute for Medical Statistics, Epidemiology and Computer Science, Benjamin Franklin Medical School, Free University of Berlin, Germany, DE aut Böhm B. Department of General, Visceral, Vascular and Thoracic Surgery, Benjamin Franklin Medical School, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Schumannstr. 20/21, D-10117l Berlin, Germany, e-mail: schwenk@charite.de, Tel.: +49-30-28025048, Fax: +49-30-28021175, DE aut Müller J. M. Department of General, Visceral, Vascular and Thoracic Surgery, Benjamin Franklin Medical School, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Schumannstr. 20/21, D-10117l Berlin, Germany, e-mail: schwenk@charite.de, Tel.: +49-30-28025048, Fax: +49-30-28021175, DE aut https://doi.org/10.1007/s004230050002 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230050002 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schwenk W. Department of General, Visceral, Vascular and Thoracic Surgery, Benjamin Franklin Medical School, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Schumannstr. 20/21, D-10117l Berlin, Germany, e-mail: schwenk@charite.de, Tel.: +49-30-28025048, Fax: +49-30-28021175, DE aut NATIONALLICENCE 700 1- Jacobi C. Department of General, Visceral, Vascular and Thoracic Surgery, Benjamin Franklin Medical School, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Schumannstr. 20/21, D-10117l Berlin, Germany, e-mail: schwenk@charite.de, Tel.: +49-30-28025048, Fax: +49-30-28021175, DE aut NATIONALLICENCE 700 1- Mansmann U. Institute for Medical Statistics, Epidemiology and Computer Science, Benjamin Franklin Medical School, Free University of Berlin, Germany, DE aut NATIONALLICENCE 700 1- Böhm B. Department of General, Visceral, Vascular and Thoracic Surgery, Benjamin Franklin Medical School, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Schumannstr. 20/21, D-10117l Berlin, Germany, e-mail: schwenk@charite.de, Tel.: +49-30-28025048, Fax: +49-30-28021175, DE aut NATIONALLICENCE 700 1- Müller J. M. Department of General, Visceral, Vascular and Thoracic Surgery, Benjamin Franklin Medical School, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Schumannstr. 20/21, D-10117l Berlin, Germany, e-mail: schwenk@charite.de, Tel.: +49-30-28025048, Fax: +49-30-28021175, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer