caa a22 4500 475790588 CHVBK 20180406123709.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s004230000169 doi (NATIONALLICENCE)springer-10.1007/s004230000169 Differential diagnosis of calcitonin-secreting neuroendocrine carcinoma of the foregut by pentagastrin stimulation [Elektronische Daten] [A. Machens, J. Haedecke, H.-J. Holzhausen, O. Thomusch, U. Schneyer, H. Dralle] Abstract.: Background and aims: This study assessed the suitability of pentagastrin stimulation in hypercalcitoninaemia for differential diagnosis of neuroendocrine carcinoma of the foregut. Patients: A prospective institutional study (March 1997-September 1999) was conducted involving all patients admitted to the pneumological and general surgical wards for small cell lung cancer (SCLC) or primary medullary thyroid carcinoma (MTC). Basal and stimulated serum calcitonin levels were measured using an improved immunoradiometrical assay for the monomeric form of calcitonin. Results: Increased basal calcitonin levels were noted in six non-MTC patients (one mediastinal and one laryngeal neuroendocrine carcinoma, and four SCLCs). Because of chronic renal failure, one SCLC patient had to be excluded. The remaining five non-MTC patients with normal renal function were compared to eight primary MTC patients. In terms of pentagastrin stimulation, an increase in serum calcitonin levels of less than twofold the baseline significantly correlated with both non-MTC (r=0.85; P=0.005) and SCLC (r=0.81; P=0.024). Immunostaining of tissue specimens for calcitonin was positive in the patients with mediastinal and laryngeal neuroendocrine carcinoma and in all eight patients with primary MTC, but was negative in the two SCLC patients with adequate tissue samples. Conclusions: Irrespective of the pathophysiological background, pentagastrin stimulation affords a differential diagnosis in neuroendocrine carcinoma of the foregut when chronic renal failure is excluded. Springer-Verlag, 2000 Neuroendocrine carcinoma Small cell lung carcinoma Medullary thyroid carcinoma Serum calcitonin Pentagastrin stimulation nationallicence Machens A. Department of General Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut Haedecke J. Department of Internal Medicine, Division of Pneumology and Endocrinology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut Holzhausen H.-J Department of Pathology, Martin Luther University Halle-Wittenberg, Magdeburger Strasse 14, 06097 Halle, Germany, Germany aut Thomusch O. Department of General Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut Schneyer U. Department of Internal Medicine, Division of Pneumology and Endocrinology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut Dralle H. Department of General Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut Langenbeck's Archives of Surgery Springer-Verlag 385/6(2000-10-01), 398-401 1435-2443 385:6<398 2000 385 423 https://doi.org/10.1007/s004230000169 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230000169 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Machens A. Department of General Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut NATIONALLICENCE 700 1- Haedecke J. Department of Internal Medicine, Division of Pneumology and Endocrinology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut NATIONALLICENCE 700 1- Holzhausen H.-J Department of Pathology, Martin Luther University Halle-Wittenberg, Magdeburger Strasse 14, 06097 Halle, Germany, Germany aut NATIONALLICENCE 700 1- Thomusch O. Department of General Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut NATIONALLICENCE 700 1- Schneyer U. Department of Internal Medicine, Division of Pneumology and Endocrinology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut NATIONALLICENCE 700 1- Dralle H. Department of General Surgery, Martin Luther University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097 Halle, Germany, Germany aut NATIONALLICENCE 773 0- Langenbeck's Archives of Surgery Springer-Verlag 385/6(2000-10-01), 398-401 1435-2443 385:6<398 2000 385 423 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer