caa a22 4500 475790596 CHVBK 20180406123709.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s004230000118 doi (NATIONALLICENCE)springer-10.1007/s004230000118 Islet cell transplantation: the future? [Elektronische Daten] [Thierry Berney, Camillo Ricordi] Abstract.: Background: Islet of Langerhans' cell transplantation is a promising strategy for the treatment of type-1 diabetes mellitus. Results of this procedure have yet to match those of whole organ pancreas transplantation, but are rapidly improving, as witnessed by increasing rates of insulin independence and graft function (i.e., C-peptide production) after islet transplantation. Discussion: Identification of obstacles to the success of islet transplantation, such as primary nonfunction, immunosuppression-related metabolic workload, or recurrence of autoimmunity, will allow the development of new strategies tailored to overcome them. In particular, novel immunosuppressive protocols, with or without the aim of inducing tolerance, and immunoisolation devices are reaching the stage of clinical applicability. Finally, several strategies, such as utilization of porcine xenogeneic islets or genetically engineered β-cell lines, or in vitro expansion of cultured β-cells could theoretically expand indefinitely the pool of islet tissue for transplantation. Springer-Verlag, 2000 Diabetes mellitus Islet cell transplantation nationallicence Berney Thierry Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10 Ave, Miami, FL 33136, USA, USA aut Ricordi Camillo Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10 Ave, Miami, FL 33136, USA, USA aut Langenbeck's Archives of Surgery Springer-Verlag 385/6(2000-10-01), 373-378 1435-2443 385:6<373 2000 385 423 https://doi.org/10.1007/s004230000118 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230000118 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berney Thierry Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10 Ave, Miami, FL 33136, USA, USA aut NATIONALLICENCE 700 1- Ricordi Camillo Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10 Ave, Miami, FL 33136, USA, USA aut NATIONALLICENCE 773 0- Langenbeck's Archives of Surgery Springer-Verlag 385/6(2000-10-01), 373-378 1435-2443 385:6<373 2000 385 423 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer