caa a22 4500 47579060X CHVBK 20180406123709.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s004230000155 doi (NATIONALLICENCE)springer-10.1007/s004230000155 Intraperitoneal delivery of insulin via mechanical pump: surgical implications [Elektronische Daten] [Robert Udelsman, Michael S. Boyne, Kimberly E. Loman, Christopher D. Saudek] Abstract.: Between November 1986 and January 2000, 28 patients with insulin-dependent diabetes mellitus were enrolled in the implanted insulin pump study at Johns Hopkins Hospital. An additional two patients underwent pump implantation under compassionate use guidelines due to apparent resistance to subcutaneously administered insulin uptake. The mean patient age was 44±10.5years. Eleven patients (39%) were female and the mean duration of diabetes was 25.7±8.9 years. Diabetic retinopathy, neuropathy, and nephropathy were present in 43%, 25% and 11% of patients, respectively. The insulin pumps functioned safely for a total of 189 patient years. Mean pump life was 26±1.2 months. There was no mortality. Morbidity was limited to pump-site infections [n=y (4%) of all pumps placed], one case of pump migration and skin erosion, and one small bowel obstruction associated with the pump catheter. Mean serum hemoglobin AIC levels before and after pump placement were 9.0±2.9% and 7.5±0.7% (P=0.0023), respectively. Correspondingly, the mean daily blood glucose levels decreased from 161±40 mg/dl before placement to 141±27 mg/dl after pump placement (P=0.0063). Intraperitoneal delivery of insulin by a mechanical pump appears to be an attractive alternative for the treatment of insulin-dependent diabetes mellitus. Springer-Verlag, 2000 Insulin-dependent diabetes mellitus Insulin pump Insulin pump implantation nationallicence Udelsman Robert The Divisions of Endocrine and Oncologic Surgery, Johns Hopkins Medical Institutions, Blalock 688, 600N. Wolfe Street, Baltimore, MD 21287, USA, USA aut Boyne Michael S. The Divisions Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Blalock 688, 600N. Wolfe Street, Baltimore, MD 21287, USA, USA aut Loman Kimberly E. The Divisions Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Blalock 688, 600N. Wolfe Street, Baltimore, MD 21287, USA, USA aut Saudek Christopher D. The Divisions Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Blalock 688, 600N. Wolfe Street, Baltimore, MD 21287, USA, USA aut Langenbeck's Archives of Surgery Springer-Verlag 385/6(2000-10-01), 367-372 1435-2443 385:6<367 2000 385 423 https://doi.org/10.1007/s004230000155 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230000155 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Udelsman Robert The Divisions of Endocrine and Oncologic Surgery, Johns Hopkins Medical Institutions, Blalock 688, 600N. Wolfe Street, Baltimore, MD 21287, USA, USA aut NATIONALLICENCE 700 1- Boyne Michael S. The Divisions Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Blalock 688, 600N. Wolfe Street, Baltimore, MD 21287, USA, USA aut NATIONALLICENCE 700 1- Loman Kimberly E. The Divisions Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Blalock 688, 600N. Wolfe Street, Baltimore, MD 21287, USA, USA aut NATIONALLICENCE 700 1- Saudek Christopher D. The Divisions Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Blalock 688, 600N. Wolfe Street, Baltimore, MD 21287, USA, USA aut NATIONALLICENCE 773 0- Langenbeck's Archives of Surgery Springer-Verlag 385/6(2000-10-01), 367-372 1435-2443 385:6<367 2000 385 423 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer