caa a22 4500 475790820 CHVBK 20180406123710.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004230050269 doi (NATIONALLICENCE)springer-10.1007/s004230050269 Tumor volume: a novel prognostic factor in patients who undergo curative resection for gastric cancer [Elektronische Daten] [S. Kikuchi, Y. Hiki, H. Shimao, Y. Sakakibara, A. Kakita] Abstract : Background and aims: The present study evaluates the significance of tumor volume as a prognostic factor in gastric cancer. Patients/methods: Tumor volume was measured from serial tissue sections of 101 patients who had undergone curative resection for solitary carcinoma of the stomach using a computer graphics analysis program. These patients were analyzed with respect to survival based on uni- variate and multivariate analyses of clinicopathological factors, including tumor volume, to determine an independent prognostic factor. Results: Significant differences in survival were found with respect to depth of tumor invasion (P=0.001), status of lymph-node metastasis (P=0.018), tumor diameter (P=0.005), and tumor volume (P<0.0001) based on univariate analysis. However, multivariate analysis indicated only tumor volume as a valid factor in determining prognosis among the nine variables and was significantly associated with the prognosis (P=0.0005; relative risk 18.23; 95% confidence interval 3.52-94.37). Conclusion: The present findings indicate that tumor volume is an important prognostic factor in patients who undergo curative resection for gastric cancer and may be an alternative to conventional factors, thus providing a novel independent prognostic factor in gastric cancer. Springer-Verlag Berlin Heidelberg, 2000 Key words Gastric cancer nationallicence Prognostic factor nationallicence Tumor volumetry nationallicence Surface rendering nationallicence Computer graphics nationallicence Kikuchi S. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Hiki Y. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Shimao H. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Sakakibara Y. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Kakita A. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut https://doi.org/10.1007/s004230050269 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230050269 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kikuchi S. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 700 1- Hiki Y. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 700 1- Shimao H. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 700 1- Sakakibara Y. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut NATIONALLICENCE 700 1- Kakita A. Department of Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, Sagamihara-shi, Kanagawa 228, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer