caa a22 4500 475790863 CHVBK 20180406123710.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004230050263 doi (NATIONALLICENCE)springer-10.1007/s004230050263 Results after nonsurgical local treatment of primary liver malignancies [Elektronische Daten] [G. Marin Hargreaves, R. Adam, H. Bismuth] Abstract : Although it is generally agreed that surgical resection is the only curative treatment for liver malignancy, this is not possible in all cases. In situ methods for destruction of liver tumors are now available. We describe recently developed methods, with an up-date based on the literature and our own experience. Under ultrasound guidance chemical agents such as ethanol, hot saline, and acetic acid may be injected into the tumor, or thermally mediated techniques involving cryotherapy, microwaves, radiofrequency, or interstitial laser photocoagulation may be applied. Also, various ways of delivering radiotherapy to primary liver cancer have been developed. Although there are few randomized studies to compare these local, nonsurgical techniques, they have been shown to improve survival and in some cases to render tumors resectable. The long-term results will show the real benefits of these newer treatments, particularly in high-risk patients. Springer-Verlag Berlin Heidelberg, 2000 Key words Hepatocellular carcinoma nationallicence Local treatment nationallicence In situ destruction nationallicence Outcome nationallicence Nonresection nationallicence Marin Hargreaves G. Centre Hépato-Biliaire, Hôpital Paul Brousse, Université Paris-Sud, Avenue Paul Vaillant Couturier, 94800 Villejuif, France e-mail: rene.adam@pbr.ap-hop-paris.fr, FR aut Adam R. Centre Hépato-Biliaire, Hôpital Paul Brousse, Université Paris-Sud, Avenue Paul Vaillant Couturier, 94800 Villejuif, France e-mail: rene.adam@pbr.ap-hop-paris.fr, FR aut Bismuth H. Centre Hépato-Biliaire, Hôpital Paul Brousse, Université Paris-Sud, Avenue Paul Vaillant Couturier, 94800 Villejuif, France e-mail: rene.adam@pbr.ap-hop-paris.fr, FR aut https://doi.org/10.1007/s004230050263 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230050263 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marin Hargreaves G. Centre Hépato-Biliaire, Hôpital Paul Brousse, Université Paris-Sud, Avenue Paul Vaillant Couturier, 94800 Villejuif, France e-mail: rene.adam@pbr.ap-hop-paris.fr, FR aut NATIONALLICENCE 700 1- Adam R. Centre Hépato-Biliaire, Hôpital Paul Brousse, Université Paris-Sud, Avenue Paul Vaillant Couturier, 94800 Villejuif, France e-mail: rene.adam@pbr.ap-hop-paris.fr, FR aut NATIONALLICENCE 700 1- Bismuth H. Centre Hépato-Biliaire, Hôpital Paul Brousse, Université Paris-Sud, Avenue Paul Vaillant Couturier, 94800 Villejuif, France e-mail: rene.adam@pbr.ap-hop-paris.fr, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer