caa a22 4500 47579088X CHVBK 20180406123710.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s004230000142 doi (NATIONALLICENCE)springer-10.1007/s004230000142 Primary and secondary hepatic manifestation of neuroendocrine tumors [Elektronische Daten] [A. Pascher, T. Steinmüller, C. Radke, N. Hosten, B. Wiedenmann, P. Neuhaus, W.O. Bechstein] Background: In comparison with most other malignancies, in the treatment of metastatic neuroendocrine tumors one also has to consider endocrine symptoms and natural progression of disease. Since hepatic metastasis predominates and endocrine symptoms correlate with functional tumor mass, hepatic resection may improve prognosis or even cure patients. Patients and methods: We reviewed 41 consecutive patients with metastatic neuroendocrine tumors and four patients with primary hepatic disease presenting between 1989 and 1999. The neuroendocrine tumors were classified according to their origin, pattern of metastasis, endocrine activity, and histology. Operative therapy including hepatic resections of different extent, liver transplantation, and removal of the primary tumor was analyzed. The median survival after initial diagnosis and after hepatic resection were major parameters of outcome. Results: There were 26 low-grade malignant, 12 high-grade malignant, 2 biphasically differentiated neuroendocrine carcinomas, and 5 pancreatic endocrine tumors. Hepatic resections were performed in 25 patients, resections of the primary tumor in 40 patients. The median survival after initial diagnosis was 49months; 50.5months in patients with hepatic resection versus 47months in those with no liver surgery. Conclusion: Hepatic resection improved the outcome of patients with liver metastasis due to neuroendocrine tumors tendentiously but not significantly. Springer-Verlag, 2000 Neuroendocrine tumors Liver metastasis Pancreatic endocrine tumors nationallicence Pascher A. Department for General, Visceral and Transplantation Surgery, Charité, Campus Virchow Clinic, Augustenburger Platz 1, D-13353 Berlin, Germany, Germany aut Steinmüller T. Department for General, Visceral and Transplantation Surgery, Charité, Campus Virchow Clinic, Augustenburger Platz 1, D-13353 Berlin, Germany, Germany aut Radke C. Department for Pathology, Charité, Campus Virchow Clinic, Augustenburgerplatz 1, D-13353 Berlin, Germany, Germany aut Hosten N. Department for Radiology, Charité, Campus Virchow Clinic, Augustenburgerplatz 1, D-13353 Berlin, Germany, Germany aut Wiedenmann B. Department for Gastroenterology and Hepatology, Charité, Campus Virchow Clinic, Augustenburgerplatz 1, D-13353 Berlin, Germany, Germany aut Neuhaus P. Department for General, Visceral and Transplantation Surgery, Charité, Campus Virchow Clinic, Augustenburger Platz 1, D-13353 Berlin, Germany, Germany aut Bechstein W.O. Department for General, Visceral and Transplantation Surgery, Charité, Campus Virchow Clinic, Augustenburger Platz 1, D-13353 Berlin, Germany, Germany aut Langenbeck's Archives of Surgery Springer-Verlag 385/4(2000-07-01), 265-270 1435-2443 385:4<265 2000 385 423 https://doi.org/10.1007/s004230000142 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230000142 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pascher A. Department for General, Visceral and Transplantation Surgery, Charité, Campus Virchow Clinic, Augustenburger Platz 1, D-13353 Berlin, Germany, Germany aut NATIONALLICENCE 700 1- Steinmüller T. Department for General, Visceral and Transplantation Surgery, Charité, Campus Virchow Clinic, Augustenburger Platz 1, D-13353 Berlin, Germany, Germany aut NATIONALLICENCE 700 1- Radke C. Department for Pathology, Charité, Campus Virchow Clinic, Augustenburgerplatz 1, D-13353 Berlin, Germany, Germany aut NATIONALLICENCE 700 1- Hosten N. Department for Radiology, Charité, Campus Virchow Clinic, Augustenburgerplatz 1, D-13353 Berlin, Germany, Germany aut NATIONALLICENCE 700 1- Wiedenmann B. Department for Gastroenterology and Hepatology, Charité, Campus Virchow Clinic, Augustenburgerplatz 1, D-13353 Berlin, Germany, Germany aut NATIONALLICENCE 700 1- Neuhaus P. Department for General, Visceral and Transplantation Surgery, Charité, Campus Virchow Clinic, Augustenburger Platz 1, D-13353 Berlin, Germany, Germany aut NATIONALLICENCE 700 1- Bechstein W.O. Department for General, Visceral and Transplantation Surgery, Charité, Campus Virchow Clinic, Augustenburger Platz 1, D-13353 Berlin, Germany, Germany aut NATIONALLICENCE 773 0- Langenbeck's Archives of Surgery Springer-Verlag 385/4(2000-07-01), 265-270 1435-2443 385:4<265 2000 385 423 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer