caa a22 4500 475791053 CHVBK 20180406123710.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s004230000167 doi (NATIONALLICENCE)springer-10.1007/s004230000167 Benign solitary fibrous tumour of the thigh: morphological, chromosomal and differential diagnostic aspects [Elektronische Daten] [Michael Krismann, Heiner Adams, Malgorzata Jaworska, Klaus-Michael Müller, Georg Johnen] Abstract.: Solitary fibrous tumours (SFTs) are rare and usually benign neoplasms of mesenchymal origin that are often found in the visceral pleura (fibrous pleural tumour, FPT) or other serosal surfaces. They have also been found in soft tissues. We report the case of an SFT localised in the thigh of an 86-year-old woman. The tumour specimen was examined morphologically, immunohistochemically and molecular genetically, using comparative genomic hybridisation (CGH). The latter detects unbalanced chromosomal alterations in human neoplasms by competitive nucleic acid hybridisation and consecutive computer image analysis. The tumour consists of fibroblast-like cells, arranged in a typical "patternless pattern". Immunohistochemically, the tumour stained positively for vimentin, CD34, CD99, and focally for actin and desmin. No reaction occurred with keratin or S100 protein antibodies. CGH detected a single loss on chromosome 13q. Springer-Verlag, 2000 Solitary fibrous tumour Thigh Immunohistochemistry Comparative genomic hybridisation nationallicence Krismann Michael Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut Adams Heiner Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut Jaworska Malgorzata Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut Müller Klaus-Michael Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut Johnen Georg Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut https://doi.org/10.1007/s004230000167 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230000167 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krismann Michael Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut NATIONALLICENCE 700 1- Adams Heiner Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut NATIONALLICENCE 700 1- Jaworska Malgorzata Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut NATIONALLICENCE 700 1- Müller Klaus-Michael Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut NATIONALLICENCE 700 1- Johnen Georg Institute of Pathology, Professional Associations' Clinic Bergmannsheil Bochum, University Clinic, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer