caa a22 4500 475791134 CHVBK 20180406123711.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004230000158 doi (NATIONALLICENCE)springer-10.1007/s004230000158 Perforated peptic ulcer: is there a difference between Eastern Europe and Germany? [Elektronische Daten] [Toomas Sillakivi, Qin Yang, Ants Peetsalu, Christian Ohmann, Study Group and Acute Abdominal Pain Study Group, Copernicus] Abstract.: Background and aims: Ulcer surgery and the epidemiology of peptic ulcer perforation have changed considerably in recent decades. Patients/methods: Within two prospective studies, 170 perforated peptic ulcer patients from 12 Eastern European centres and 37 patients from 11 German centres were analysed. Results: The median age of patients was 43years in the Copernicus study and 49years in the MEDWIS study (P=n.s.), being higher for MEDWIS female patients (73 vs 53years, respectively; P<0.05). Female patients made up 17% (29/170) of the Copernicus study and 35% (40/170) of the MEDWIS study (P<0.05). Twenty-three per cent (40/170) of patients in the Copernicus study and 54% (20/37) in the MEDWIS study had gastric ulcer perforation (P<0.001). The proportion of definitive operations was higher in Eastern Europe (41.1%; 67/163) than it was in Germany (16.1%; 5/31) (P<0.01). German patients experienced more general complications than Eastern European patients (35 vs 12%, respectively; P<0.01) and a higher mortality [13% (5/37) vs 2% (4/170), respectively; P<0.01]. Delayed admission ≥12h and age ≥60years remained predictors for complications in multivariate logistic regression analysis. Conclusion: The proportion of both women and gastric ulcers was higher among German patients, while Eastern European patients underwent more definitive operations. German patients experienced more general complications and a higher mortality. Complications were related to high age and delayed admission. Springer-Verlag, 2000 Perforated peptic ulcer Operative treatment Complications Risk factors nationallicence Sillakivi Toomas Department of Surgery, University of Tartu, Puusepa 8, 51014 Tartu, Estonia aut Yang Qin Coordination Centre for Clinical Trials and Theoretical Surgery Unit, Department of General and Trauma Surgery, H. Heine University of Düsseldorf, Germany aut Peetsalu Ants Department of Surgery, University of Tartu, Puusepa 8, 51014 Tartu, Estonia aut Ohmann Christian Coordination Centre for Clinical Trials and Theoretical Surgery Unit, Department of General and Trauma Surgery, H. Heine University of Düsseldorf, Germany aut Copernicus Study Group and Acute Abdominal Pain Study Group, aut https://doi.org/10.1007/s004230000158 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230000158 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sillakivi Toomas Department of Surgery, University of Tartu, Puusepa 8, 51014 Tartu, Estonia aut NATIONALLICENCE 700 1- Yang Qin Coordination Centre for Clinical Trials and Theoretical Surgery Unit, Department of General and Trauma Surgery, H. Heine University of Düsseldorf, Germany aut NATIONALLICENCE 700 1- Peetsalu Ants Department of Surgery, University of Tartu, Puusepa 8, 51014 Tartu, Estonia aut NATIONALLICENCE 700 1- Ohmann Christian Coordination Centre for Clinical Trials and Theoretical Surgery Unit, Department of General and Trauma Surgery, H. Heine University of Düsseldorf, Germany aut NATIONALLICENCE 700 1- Copernicus Study Group and Acute Abdominal Pain Study Group aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer