caa a22 4500 475791177 CHVBK 20180406123711.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004230050251 doi (NATIONALLICENCE)springer-10.1007/s004230050251 Helicobacter pylori in the upper gastrointestinal tract: medical or surgical treatment of gastric lymphoma? [Elektronische Daten] [H. -D. Röher, P. R. Verreet, O. Wörmer, F. P. Müller, C. Ohmann, W. Fischbach] Abstract : The treatment of primary gastric lymphoma is controversial. The role of surgery has come to be questioned with increasing knowledge about the pathogenesis of gastric lymphoma and with new therapeutic approaches such as eradication of Helicobacter pylori. We review published clinical trials of primary gastric lymphoma, including preliminary results of our own prospective multicenter trial. The results of 7 trials of H. pylori eradication and 12 prospective therapeutic trials trial are discussed. On basis of these data it is concluded that surgery with intention of R0 resection is the treatment of choice in stages EI2 and EII1 of low-grade lymphoma. In high-grade lymphomas it is still unclear whether surgery or its primary combination with radio- or chemotherapy should be preferred. The eradication of H. pylori is a promising therapeutic approach for localized low-grade mucosa-associated lymphoid tissue lymphoma. A randomized trial is needed to clarify whether medical or surgical management of localized gastric lymphoma or a combination of two is the best treatment modality. Springer-Verlag Berlin Heidelberg, 2000 Key words Gastric lymphoma nationallicence Review nationallicence Prospective study nationallicence Surgical treatment nationallicence Helicobacter pylori nationallicence Röher H. -D Department of General and Trauma Surgery, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany, DE aut Verreet P. R. Department of General and Visceral Surgery, Center for Surgery, Klinikum Krefeld, Germany, DE aut Wörmer O. Department of General and Trauma Surgery, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany, DE aut Müller F. P. Department of General and Visceral Surgery, Center for Surgery, Klinikum Krefeld, Germany, DE aut Ohmann C. Department of General and Trauma Surgery, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany, DE aut Fischbach W. Medical Department II, Klinikum Aschaffenburg, Germany, DE aut https://doi.org/10.1007/s004230050251 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230050251 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Röher H. -D Department of General and Trauma Surgery, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany, DE aut NATIONALLICENCE 700 1- Verreet P. R. Department of General and Visceral Surgery, Center for Surgery, Klinikum Krefeld, Germany, DE aut NATIONALLICENCE 700 1- Wörmer O. Department of General and Trauma Surgery, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany, DE aut NATIONALLICENCE 700 1- Müller F. P. Department of General and Visceral Surgery, Center for Surgery, Klinikum Krefeld, Germany, DE aut NATIONALLICENCE 700 1- Ohmann C. Department of General and Trauma Surgery, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany, DE aut NATIONALLICENCE 700 1- Fischbach W. Medical Department II, Klinikum Aschaffenburg, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer