caa a22 4500 475791207 CHVBK 20180406123711.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004230050255 doi (NATIONALLICENCE)springer-10.1007/s004230050255 Impact of 18F-FDG-positron emission tomography for decision making in colorectal cancer recurrences [Elektronische Daten] [A. Imdahl, M. J. Reinhardt, E. U. Nitzsche, M. Mix, A. Dingeldey, A. Einert, P. Baier, E. H. Farthmann] Abstract : Diagnostic imaging for suspected tumour recurrence of primary colorectal cancer frequently lacks specificity and sensitivity. The impact of whole body 18F-FDG-positron-emission tomography (PET) on detection of local recurrences and hepatic or pulmonary metastases was evaluated in a prospective study. Results were compared with computed tomography (CT), ultrasonography, magnetic resonance imaging and conventional chest X-ray. The study included 71 patients (77 investigations) with suspected local recurrence, hepatic metastases or unexplained raised level of the tumour marker carcinoembryonic antigen (CEA). The results demonstrate that 18F-FDG-PET was clearly superior to CT with regard to detection of hepatic metastases. Sensitivity was 1.0 and specificity 0.98 compared with 0.87 and 0.91 for CT. In four cases, 18F-FDG-PET clarified otherwise unclear local recurrences. In five patients, 18F-FDG-PET showed pulmonary metastases that had previously been unknown. In a total of 16 patients (20.8%), 18F-FDG-PET provided additional information leading to a change of the treatment strategy. 18F-FDG-PET clearly has the ability to detect colorectal tumour recurrence and its metastases in a whole body format. Therefore, it may be applied in the follow-up of patients with primary colorectal cancer. Despite the costs, it is certainly recommended for patients with an otherwise unclear increase of CEA level or with unproven local recurrence. Springer-Verlag Berlin Heidelberg, 2000 Key words Colorectal cancer recurrence nationallicence PET nationallicence Liver metastases nationallicence Imdahl A. Department of Surgery, Division of General Surgery, University of Freiburg, Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany e-mail: imdahl@ch11.ukl.uni-freiburg.de, DE aut Reinhardt M. J. Department of Radiology, Division of Nuclear Medicine, University of Freiburg, Medical Center, Freiburg, Germany, DE aut Nitzsche E. U. Department of Radiology, Division of Nuclear Medicine, University of Freiburg, Medical Center, Freiburg, Germany, DE aut Mix M. Department of Radiology, Division of Nuclear Medicine, University of Freiburg, Medical Center, Freiburg, Germany, DE aut Dingeldey A. Department of Surgery, Division of General Surgery, University of Freiburg, Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany e-mail: imdahl@ch11.ukl.uni-freiburg.de, DE aut Einert A. Department of Radiology, Division of Radiodiagnostic, University of Freiburg, Medical Center, Freiburg, Germany, DE aut Baier P. Department of Surgery, Division of General Surgery, University of Freiburg, Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany e-mail: imdahl@ch11.ukl.uni-freiburg.de, DE aut Farthmann E. H. Department of Surgery, Division of General Surgery, University of Freiburg, Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany e-mail: imdahl@ch11.ukl.uni-freiburg.de, DE aut https://doi.org/10.1007/s004230050255 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004230050255 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Imdahl A. Department of Surgery, Division of General Surgery, University of Freiburg, Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany e-mail: imdahl@ch11.ukl.uni-freiburg.de, DE aut NATIONALLICENCE 700 1- Reinhardt M. J. Department of Radiology, Division of Nuclear Medicine, University of Freiburg, Medical Center, Freiburg, Germany, DE aut NATIONALLICENCE 700 1- Nitzsche E. U. Department of Radiology, Division of Nuclear Medicine, University of Freiburg, Medical Center, Freiburg, Germany, DE aut NATIONALLICENCE 700 1- Mix M. Department of Radiology, Division of Nuclear Medicine, University of Freiburg, Medical Center, Freiburg, Germany, DE aut NATIONALLICENCE 700 1- Dingeldey A. Department of Surgery, Division of General Surgery, University of Freiburg, Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany e-mail: imdahl@ch11.ukl.uni-freiburg.de, DE aut NATIONALLICENCE 700 1- Einert A. Department of Radiology, Division of Radiodiagnostic, University of Freiburg, Medical Center, Freiburg, Germany, DE aut NATIONALLICENCE 700 1- Baier P. Department of Surgery, Division of General Surgery, University of Freiburg, Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany e-mail: imdahl@ch11.ukl.uni-freiburg.de, DE aut NATIONALLICENCE 700 1- Farthmann E. H. Department of Surgery, Division of General Surgery, University of Freiburg, Medical Center, Hugstetterstrasse 55, D-79106 Freiburg, Germany e-mail: imdahl@ch11.ukl.uni-freiburg.de, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer