caa a22 4500 475791282 CHVBK 20180406123711.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1006315127220 doi (NATIONALLICENCE)springer-10.1023/A:1006315127220 Reduced early diastolic inflow velocities in the antero-posterior transverse direction in the left ventricle of patients with dilated cardiomyopathy [Elektronische Daten] [Shinichi Fujimoto, Yoshihito Nakagawa, Reiko Mizuno, Shiro Nakanishi, Kazuhiro Dohi] In patients with dilated cardiomyopathy (DCM), the left ventricular (LV) inflow jet is narrow and has a high pressure gradient. A pulsed Doppler restrictive transmitral flow pattern is a characteristic feature of severe left ventricular disease. However, Doppler flow analysis is limited by the angle between the blood flow jet and the ultrasonic beam. In this study we used gated magnetic resonance imaging (MRI) to investigate the inflow velocity in the LV transverse directions during early diastole in patients with DCM. Methods: We studied 10 patients with DCM (mean age: 47 y). Ten age-matched healthy volunteers were also examined. Gradient echo images of the LV were obtained. Left ventricular short axis phase contrast images were obtained at the level of the mitral valve tip and 1 cm inside the LV. Long axis images were also obtained. Through-plane peak velocities at peak early diastolic filling were measured along the LV long axis, antero-posterior short axis, and right-left short axis. Blood velocity was measured in 50 ms blocks. Results: Early diastolic inflow velocity along the long axis, especially at the center of the LV, was well preserved in DCM. However, the inflow velocity in the antero-posterior transverse direction of the LV (i.e., in the direction of mitral valve excursion) was significantly reduced in DCM. Conclusions: Early diastolic inflow velocity in the antero-posterior transverse direction of the LV is reduced in patients with DCM indicating that the vector component of the forces acting in the antero-posterior transverse direction of the LV may be decreased in patients with DCM during early diastolic filling. Kluwer Academic Publishers, 2000 diastolic function nationallicence dilated cardiomyopathy nationallicence left ventricular transverse inflow velocity nationallicence Fujimoto Shinichi Department of Clinico-Laboratory Diagnostics, Nara Medical University, Nara, Japan aut Nakagawa Yoshihito First Department of Internal Medicine, Nara Medical University, Nara, Japan aut Mizuno Reiko First Department of Internal Medicine, Nara Medical University, Nara, Japan aut Nakanishi Shiro Hirai Hospital, Kashihara, Nara, Japan aut Dohi Kazuhiro First Department of Internal Medicine, Nara Medical University, Nara, Japan aut The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/1(2000-02-01), 43-48 0167-9899 16:1<43 2000 16 10554 https://doi.org/10.1023/A:1006315127220 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006315127220 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujimoto Shinichi Department of Clinico-Laboratory Diagnostics, Nara Medical University, Nara, Japan aut NATIONALLICENCE 700 1- Nakagawa Yoshihito First Department of Internal Medicine, Nara Medical University, Nara, Japan aut NATIONALLICENCE 700 1- Mizuno Reiko First Department of Internal Medicine, Nara Medical University, Nara, Japan aut NATIONALLICENCE 700 1- Nakanishi Shiro Hirai Hospital, Kashihara, Nara, Japan aut NATIONALLICENCE 700 1- Dohi Kazuhiro First Department of Internal Medicine, Nara Medical University, Nara, Japan aut NATIONALLICENCE 773 0- The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/1(2000-02-01), 43-48 0167-9899 16:1<43 2000 16 10554 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer