caa a22 4500 475791398 CHVBK 20180406123712.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1010604913656 doi (NATIONALLICENCE)springer-10.1023/A:1010604913656 Diagnostic value of resting tricuspid regurgitation velocity and right ventricular ejection flow parameters for the detection of exercise induced pulmonary arterial hypertension [Elektronische Daten] [Eduardo Bossone, Erick Avelar, David Bach, Brenda Gillespie, Melvyn Rubenfire, William Armstrong] Our objectives were to evaluate resting tricuspid regurgitation velocity (TRV) and right ventricular outflow tract velocity curve (RVOTvc) profiles as markers for development of exercise induced pulmonary arterial hypertension (ExPHT). ExPHT is an elusive cause of dyspnea and fatigue. When present, Doppler echocardiography can detect and quantify elevated pulmonary pressure. However, the characteristics and diagnostic value of resting TRV and RVOTvc indices in patients with ExPHT have not been fully addressed. The study population consisted of 52 subjects (mean age 40.5 ± 10.9, range 22-68 years) and was divided into three subsets as follows: 1. Patients (n = 22) with overt pulmonary hypertension (PHT), 2. Patients (n = 8) with ExPHT, 3. Healthy, asymptomatic volunteers (n = 22). RVOTvcindices included: Mean and peak velocity, systolic velocity time integral (VTI); velocity time integral at peak velocity (VTImax), acceleration time; ejection time. TRV was used as an index of pulmonary artery systolic pressure. There were significant differences between normals and ExPHT for TRV, acceleration time, VTIVmax. TRV and VTImax were predictive of EXPHT in a logistic regression model. Conclusion: (1) Patients with ExPHT have distinct Doppler velocity patterns suggesting the presence of a compromised pulmonary vascular bed even with normal pulmonary pressure at rest. (2) TRV and RVOTvc indices have potential diagnostic value in the early detection of ExPHT. Kluwer Academic Publishers, 2000 Doppler echocardiography nationallicence exercise induced pulmonary hypertension nationallicence pulmonary arterial hypertension nationallicence Bossone Eduardo Department of Echocardiographic Research, San Donato Hospital, University of Milan, Italy aut Avelar Erick Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut Bach David Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut Gillespie Brenda Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut Rubenfire Melvyn Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut Armstrong William Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/6(2000-12-01), 429-436 0167-9899 16:6<429 2000 16 10554 https://doi.org/10.1023/A:1010604913656 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1010604913656 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bossone Eduardo Department of Echocardiographic Research, San Donato Hospital, University of Milan, Italy aut NATIONALLICENCE 700 1- Avelar Erick Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut NATIONALLICENCE 700 1- Bach David Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut NATIONALLICENCE 700 1- Gillespie Brenda Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut NATIONALLICENCE 700 1- Rubenfire Melvyn Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut NATIONALLICENCE 700 1- Armstrong William Division of Cardiology, Department of Internal Medicine, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan, Italy aut NATIONALLICENCE 773 0- The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/6(2000-12-01), 429-436 0167-9899 16:6<429 2000 16 10554 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer