caa a22 4500 475791525 CHVBK 20180406123712.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1006429603062 doi (NATIONALLICENCE)springer-10.1023/A:1006429603062 Aortic root asymmetry in Marfan patients; evaluation by magnetic resonance imaging and comparison with standard echocardiography [Elektronische Daten] [Lilian Meijboom, Maarten Groenink, Ernst van der Wall, Hans Romkes, Jaap Stoker, Barbara Mulder] Background: Patients with Marfan syndrome may develop aortic root dissection despite only mild aortic root dilation as shown by standard echocardiography, which may be due to aortic root asymmetry. Purpose of the present study was to investigate aortic root asymmetry by magnetic resonance (MR) imaging in patients with Marfan syndrome and to compare these measurements with standardly performed echocardiography. Methods: Eighty-seven Marfan patients (mean age 31 ± 8 years) underwent MR imaging. From this population, 15 patients (mean age 29 ± 3 years) were selected in whom both echocardiography and MR imaging had been performed within 3 months. With echocardiography, the aortic root was measured according to the recommendations of the American Society of Echocardiography. With MR imaging, a short axis view of the aortic root was obtained to measure distances between the noncoronary, right coronary and left coronary cusps and the aortic root area. Correlations between aortic root area and diameters were assessed, and 95% confidence intervals (95% CIs) calculated. Results: No difference in the standardly measured noncoronary to right coronary cusp diameter between MR imaging and echocardiography was shown (42 ± 6 mm). Largest aortic root diameter on the MR images was the right to left coronary cusp diameter (46 ± 7 mm, p < 0.02). For a given noncoronary to right coronary cusp diameter, 95% confidence intervals revealed a variation of −20 to +20% in the aortic root area. Conclusions: The majority of Marfan patients show asymmetric dilation of the aortic root by MR imaging. This phenomenon may go unnoticed when standard echocardiography is performed. The asymmetry of the aortic root might be of clinical importance in unexpected aortic root dissection. Kluwer Academic Publishers, 2000 aortic root nationallicence echocardiography nationallicence magnetic resonance imaging nationallicence Marfan syndrome nationallicence Meijboom Lilian Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands aut Groenink Maarten Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands aut van der Wall Ernst Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands aut Romkes Hans Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands aut Stoker Jaap Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands aut Mulder Barbara Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands aut The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/3(2000-06-01), 161-168 0167-9899 16:3<161 2000 16 10554 https://doi.org/10.1023/A:1006429603062 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006429603062 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meijboom Lilian Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Groenink Maarten Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Wall Ernst Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Romkes Hans Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Stoker Jaap Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Mulder Barbara Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/3(2000-06-01), 161-168 0167-9899 16:3<161 2000 16 10554 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer