caa a22 4500 47579155X CHVBK 20180406123712.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1023/A:1026592629450 doi (NATIONALLICENCE)springer-10.1023/A:1026592629450 Enhanced methods for visualizing myocardial perfusion with peripheral venous injection of Levovist®: Application of triggered harmonic imaging and triggered harmonic power Doppler imaging techniques [Elektronische Daten] [Keiji Hirooka, Kunio Miyatake, Akihisa Hanatani, Kazuo Komamura, Satoshi Nakatani, Yoshio Yasumura, Masakazu Yamagishi] Objectives:The purpose of this study was to determine whether triggered harmonic imaging (THI) or triggered harmonic power Doppler imaging (THPDI) could obtain the myocardial contrast enhancement using peripheral venous injection of a first generation echocardiographic contrast agent, Levovist®. Methods:In a phantom model, we examined the influence of an acoustic power, harmonic filters, transmitted frequencies and focus positions of transducer on Levovist®. Then fundamental, harmonic or harmonic power Doppler imaging were performed with ECG-triggered imaging in eight closed-chest dogs using bolus injection of Levovist®. Results:In a phantom model, the highest transmission power (Mechanical index 1.6), a medium harmonic filter and a focus position (6 cm) resulted in the best enhanced contrast in both THI and THPDI. Furthermore, higher pulse repetition frequency (5500 Hz) of harmonic power Doppler made clearer enhancement. In animal models, we could not observe the apparent myocardial contrast using triggered fundamental imaging, and the intensity of each region of interest (ROI) of myocardium had not changed significantly. However, homogeneous myocardial contrast could be obtained using THI, which was conditioned on the highest transmission power, a medium harmonic filter same as the phantom model, at a lower transmitted frequency (1.8 MHz) and a focus position, which were located in the middle portion of the left ventricle. The peak intensity of each ROI increased significantly in a gray level. Furthermore, THPDI caused emphasized myocardial contrast visually. Conclusions:These results indicate that THI and THPDI produce obvious MCE using peripheral venous injection of Levovist®. Kluwer Academic Publishers, 2000 harmonic imaging nationallicence microbubbles nationallicence myocardial contrast echocardiography nationallicence peripheral venous injection nationallicence power Doppler nationallicence Hirooka Keiji The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut Miyatake Kunio The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut Hanatani Akihisa The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut Komamura Kazuo Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Osaka, Japan aut Nakatani Satoshi The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut Yasumura Yoshio The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut Yamagishi Masakazu The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/4(2000-08-01), 233-246 0167-9899 16:4<233 2000 16 10554 https://doi.org/10.1023/A:1026592629450 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026592629450 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hirooka Keiji The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Miyatake Kunio The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Hanatani Akihisa The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Komamura Kazuo Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Nakatani Satoshi The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Yasumura Yoshio The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Yamagishi Masakazu The Cardiology Division of Medicine, Research Institute, National Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 773 0- The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/4(2000-08-01), 233-246 0167-9899 16:4<233 2000 16 10554 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer