caa a22 4500 475791584 CHVBK 20180406123712.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1023/A:1026539708034 doi (NATIONALLICENCE)springer-10.1023/A:1026539708034 Anatomical M-mode: A novel technique for the quantitative evaluation of regional wall motion analysis during dobutamine echocardiography [Elektronische Daten] [Jonathan Chan, Sudhir Wahi, Peter Cain, Thomas Marwick] Recognition of abnormal wall motion during dobutamine echocardiography requires an expert observer. Anatomical M-mode echocardiography may offer a novel quantitative approach to interpretation, amenable to less expert readers. We studied the application of this new modality to 124 patients (80 with known coronary anatomy and 44 patients at low probability of coronary disease) who underwent dobutamine echocardiography, using a standard protocol. Wall motion was interpreted by an experienced reader, using digitally stored 2-dimensional echocardiographic images at rest and peak stress. Percentage of systolic thickening was measured offline using anatomical M-mode echocardiography in the basal and mid segments at rest and peak dose, and compared with wall motion scores and coronary angiography. Of 729 segments, wall motion was identified as normal in 449, ischemic or viable in 171 and showed resting WM abnormalities only in 109 segments. After exclusion of the apex, anatomical M-mode measurements were feasible in 729 of 960 possible basal- and mid-zone segments (76%). Measurement of systolic thickening at peak dose was reproducible within (r 2 = 0.83) and between observers (r 2 = 0.93). Systolic thickening was significantly greater in segments with normal wall motion (37 ± 2%) compared with ischemic or viable segments (30 ± 2%, p < 0.001), and scar segments (23 ± 3%, p < 0.001). There was an increment of thickening from rest to stress in normal and viable segments, no change in scar, and a decrement in ischemic segments. Significant coronary artery disease (defined by stenoses >70% diameter) was present in 59 patients. Systolic thickening showed significant variation between segments interpreted by wall motion scoring and angiography as true and false positive and true and false negative (p < 0.05). Measurement of systolic thickening using anatomical M-mode echocardiography offers an objective method to quantify systolic thickening at dobutamine echocardiography but has limited clinical feasibility. Kluwer Academic Publishers, 2000 dobutamine echocardiography nationallicence M-mode echocardiography nationallicence quantitation nationallicence Chan Jonathan University of Queensland, Brisbane, Australia aut Wahi Sudhir University of Queensland, Brisbane, Australia aut Cain Peter University of Queensland, Brisbane, Australia aut Marwick Thomas University of Queensland, Brisbane, Australia aut The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/4(2000-08-01), 247-255 0167-9899 16:4<247 2000 16 10554 https://doi.org/10.1023/A:1026539708034 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026539708034 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chan Jonathan University of Queensland, Brisbane, Australia aut NATIONALLICENCE 700 1- Wahi Sudhir University of Queensland, Brisbane, Australia aut NATIONALLICENCE 700 1- Cain Peter University of Queensland, Brisbane, Australia aut NATIONALLICENCE 700 1- Marwick Thomas University of Queensland, Brisbane, Australia aut NATIONALLICENCE 773 0- The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/4(2000-08-01), 247-255 0167-9899 16:4<247 2000 16 10554 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer