caa a22 4500 475791711 CHVBK 20180406123712.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1026536510821 doi (NATIONALLICENCE)springer-10.1023/A:1026536510821 Accurate measures of left ventricular ejection fraction using electron beam tomography: A comparison with radionuclide angiography, and cine angiography [Elektronische Daten] [Howard Baik, Matthew Budoff, Kathleen Lane, Hamid Bakhsheshi, Bruce Brundage] Background: Quantitative determination of ejection fraction is predicated on precise measurement of end-diastolic and end-systolic volumes of the left ventricle. Contrast enhanced electron beam tomography (EBT), with excellent temporal and spatial resolution, has the potential for highly accurate measures of ejection fraction. Methods: EBT protocol used a short axis scan of the left ventricle (8-12 levels, apex to base) during infusion of iodinated contrast. To assess the accuracy of the measured left ventricular ejection fraction (LVEF), we compared EBT with first-pass radionuclide angiography (RNA) and cine angiography (CINE). Results: A total of 41 patients (26 men and 15 women) underwent all three tests within 1 week. Resting ejection fraction using each modality was assessed in a linear regression model to assess inter-test correlation with the other two modalities. Correlation between CINE and EBT was high (r = 0.90, intercept 4.67, p < 0.001). Similarly, correlation of CINE and RNA (r = 0.87, intercept −5.48, p < 0.001) and between EBT and RNA (r = 0.87, intercept −4.6, p < 0.001) were high. In a subset of those patients with LVEF ≤ 40%, correlation was consistently high between EBT and CINE. However, correlations were poor for the comparisons between RNA and CINE (r = 0.40), and between the RNA and EBT (r = 0.47). The mean differences of measured ejection fractions between each of the imaging modality were small. However, there was only modest agreement between each of the comparisons as measured using 95% confidence interval (CI) on Bland-Altman plots. Conclusion: These data indicate that the LVEF results are comparable among EBT, RNA, and CINE and can be used interchangeably to assess ventricular function for LVEF > 40%. For LVEF ≤ 40%, we demonstrated some disparate results between cine angiography and RNA and between EBT and RNA, indicating that CINE or EBT may provide more accurate assessment. Kluwer Academic Publishers, 2000 catheterization angiography nationallicence cine angiography nationallicence ejection fraction nationallicence electron beam tomography nationallicence electron beam computed tomography nationallicence radionuclide angiography nationallicence Baik Howard Harbor-UCLA Medical Center, USA aut Budoff Matthew Harbor-UCLA Medical Center, USA aut Lane Kathleen Harbor-UCLA Medical Center, USA aut Bakhsheshi Hamid Harbor-UCLA Medical Center, USA aut Brundage Bruce Harbor-UCLA Medical Center, USA aut The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/5(2000-10-01), 391-398 0167-9899 16:5<391 2000 16 10554 https://doi.org/10.1023/A:1026536510821 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026536510821 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baik Howard Harbor-UCLA Medical Center, USA aut NATIONALLICENCE 700 1- Budoff Matthew Harbor-UCLA Medical Center, USA aut NATIONALLICENCE 700 1- Lane Kathleen Harbor-UCLA Medical Center, USA aut NATIONALLICENCE 700 1- Bakhsheshi Hamid Harbor-UCLA Medical Center, USA aut NATIONALLICENCE 700 1- Brundage Bruce Harbor-UCLA Medical Center, USA aut NATIONALLICENCE 773 0- The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/5(2000-10-01), 391-398 0167-9899 16:5<391 2000 16 10554 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer