caa a22 4500 475791754 CHVBK 20180406123713.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1026558824664 doi (NATIONALLICENCE)springer-10.1023/A:1026558824664 Reliability of mechanical and phased-array designs for serial intravascular ultrasound examinations [Elektronische Daten] [Jean-Claude Tardif, Olivier Bertrand, Rosaire Mongrain, Jacques Lespérance, Jean Grégoire, Patrice Paiement, Raoul Bonan] Background: Both mechanical and multi-element intravascular ultrasound designs have potential advantages and limitations that may impact on their value for clinical and research purposes. Determination of the reproducibility of measurements is critical before a given system can be used in studies such as regression of atherosclerosis trials. Methods: We performed serial intravascular ultrasound imaging with catheters using mechanical and phased-array designs in stented and non-stented coronary arteries in dogs and in patients. Results: Both systems correlated well for areas (r ≥ 0.90, p < 0.0001) and diameters (r ≥ 0.84, p < 0.0001) in dogs and in patients. There was a slight difference between multi-element and mechanical designs for measurements of area (mean difference in dogs and in patients: −0.24 and 0.96 mm2, p < 0.055) and diameter (−0.08 and 0.16 mm, p < 0.0001). The reproducibility of the multi-element system for reanalysis of the same frames and for analysis of serial pullbacks was similar to the same measurements with the mechanical system (r ≥ 0.96 for all measurements). The differences in absolute and relative variability between the mechanical and phased-array designs, both for reanalysis of same frames and serial pullbacks, were very small. Conclusions: Although multi-element and mechanical intravascular ultrasound designs are not strictly interchangeable, their similar reproducibility and the small differences in measurements demonstrate that both designs are acceptable alternatives for trials of regression of atherosclerosis. Determination of the variability for serial pullbacks of both designs was also important to assess the statistical power of such trials. Kluwer Academic Publishers, 2000 atherosclerosis nationallicence coronary nationallicence intravascular ultrasound nationallicence stenting nationallicence Tardif Jean-Claude Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut Bertrand Olivier Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut Mongrain Rosaire Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut Lespérance Jacques Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut Grégoire Jean Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut Paiement Patrice Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut Bonan Raoul Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/5(2000-10-01), 365-375 0167-9899 16:5<365 2000 16 10554 https://doi.org/10.1023/A:1026558824664 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026558824664 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tardif Jean-Claude Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Bertrand Olivier Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Mongrain Rosaire Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Lespérance Jacques Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Grégoire Jean Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Paiement Patrice Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Bonan Raoul Interventional Cardiology Laboratories, Montreal Heart Institute, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/5(2000-10-01), 365-375 0167-9899 16:5<365 2000 16 10554 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer