caa a22 4500 475791819 CHVBK 20180406123713.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1006333619358 doi (NATIONALLICENCE)springer-10.1023/A:1006333619358 Assessment of coronary compensatory enlargement by three-dimensional intravascular ultrasound [Elektronische Daten] [Jon Klingensmith, D. Vince, Barry Kuban, Raj Shekhar, E. Tuzcu, Steven Nissen, J. Cornhill] Several techniques have been used to demonstrate that human arteries respond to atherosclerosis by increasing their total arterial area to prevent a decrease in blood flow. Three-dimensional reconstructions of coronary arteries can document this compensatory response accurately and specifically. Seven human coronary arteries were reconstructed using intravascular ultrasound and biplane angiography, and vessel geometries were quantified. In all seven vessels, as plaque area increased, overall vessel area increased (R = 0.986, 0.933, 0.984, 0.678, 0.763, 0.963, and 0.830), but luminal cross-sectional area did not significantly decrease. Focal compensatory enlargement was identified in each vessel, and in some cases this response appeared to occur until the vessel was 65% occluded. Luminal enlargement near the proximal ends was attributed to the natural taper of the vessel. The semi-automated, three-dimensional segmentation technique used in this study allows reproducible quantification, as there is no subjective manual tracing involved. Following the intravascular ultrasound transducer in time and space with biplane angiography allows for accurate reconstruction with or without automated pullback devices. Information on the rate of change of vessel measurements is also presented, which, when combined with visualization of accurate 3D geometry, provides a unique assessment of coronary compensatory enlargement. This reconstruction technique can be applied in a clinical environment with no major modification. Kluwer Academic Publishers, 2000 atherosclerosis nationallicence coronary vessels nationallicence intravascular ultrasonography nationallicence Klingensmith Jon Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut Vince D. Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut Kuban Barry Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut Shekhar Raj Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut Tuzcu E. Department of Cardiology, The Cleveland Clinic Foundation, 44195, Cleveland, OH, USA aut Nissen Steven Department of Cardiology, The Cleveland Clinic Foundation, 44195, Cleveland, OH, USA aut Cornhill J. Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/2(2000-04-01), 87-98 0167-9899 16:2<87 2000 16 10554 https://doi.org/10.1023/A:1006333619358 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1006333619358 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Klingensmith Jon Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Vince D. Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Kuban Barry Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Shekhar Raj Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Tuzcu E. Department of Cardiology, The Cleveland Clinic Foundation, 44195, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Nissen Steven Department of Cardiology, The Cleveland Clinic Foundation, 44195, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Cornhill J. Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, 44195, Cleveland, OH, USA aut NATIONALLICENCE 773 0- The International Journal of Cardiac Imaging Kluwer Academic Publishers 16/2(2000-04-01), 87-98 0167-9899 16:2<87 2000 16 10554 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer